Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity
| Autor: | Pei Wei Shueng, Wen Jing Hsu, Cheng Wei Lin, Kun Ying Lu, Jia Zih Dai, Wei Cheng Lee, Wen-Fu Lee, Chu Hung Chung, Fwu Long Mi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_treatment
Biophysics Bioengineering Photodynamic therapy 02 engineering and technology Biomaterials 03 medical and health sciences chemistry.chemical_compound Polysaccharides Cell Line Tumor medicine Humans Photosensitizer Hypoxia 030304 developmental biology 0303 health sciences Tumor microenvironment Photosensitizing Agents Tumor hypoxia Fucoidan Oxides Immunosuppression Immunotherapy 021001 nanoscience & nanotechnology Verteporfin Manganese Compounds Photochemotherapy chemistry Mechanics of Materials Ceramics and Composites Cancer research Nanoparticles 0210 nano-technology medicine.drug |
| Zdroj: | Biomaterials. 257:120227 |
| ISSN: | 0142-9612 |
| DOI: | 10.1016/j.biomaterials.2020.120227 |
| Popis: | Multifunctional nanoplatforms combined with photodynamic therapy (PDT) and anticancer drugs have shown great promising in cancer therapy. However, their efficacy is limited by the low specificity, low oxygen levels, and a tolerant tumor immune microenvironment. Herein, we developed a biocompatible theranostic nanoplatform (FM@VP) based on co-assembly of a nanocomplex formed by a functional polysaccharide fucoidan and a bioreducible polyamidoamine (PAMAM) dendrimer, a photosensitizer verteporfin (VP), and MnO2 nanoparticles (a tumor microenvironment responsive oxygen evolving nanomaterial) into a multifunctional nanoparticle cluster. The dendrimer-fucoidan polyionic nanocomplex (DFPN) specifically targeted P-selectin-overexpressed triple-negative breast cancer (TNBC) and the tumor-associated vasculature, and was sensitive to glutathione (GSH) in tumor. More importantly, this FM@VP nanocomplex simultaneously overcame tumor hypoxia, suppressed oncogenic signaling, and attenuated tumor-mediated immunosuppression, resulting in improving therapeutic efficacy of PDT while enhancing antitumor immunity and anti-metastasis. This discovery provides a powerful strategy for synergetic cancer targeting/photodynamic/immunotherapy and could serve as a safe clinical translational approach. |
| Databáze: | OpenAIRE |
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