An ‘on-demand’ photothermal antibiotic release cryogel patch: evaluation of efficacy on an ex vivo model for skin wound infection
| Autor: | Michael Pastore, Anna Rita Cantelmo, Alexandre Barras, Rana Sanyal, Sabine Szunerits, Léa Rosselle, Amitav Sanyal, Duygu Aydin, Laura Chambre, Nadia Skandrani, Rabah Boukherroub |
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| Přispěvatelé: | Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), ANR-16-IDEX-0004,ULNE,ULNE(2016) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
Biomedical Engineering Human skin 02 engineering and technology Skin infection medicine.disease_cause Methacrylate 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Humans General Materials Science ComputingMilieux_MISCELLANEOUS Skin integumentary system Chemistry [CHIM.MATE]Chemical Sciences/Material chemistry Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease 3. Good health Anti-Bacterial Agents Wound Infection 0210 nano-technology Wound healing Ethylene glycol Ex vivo Cryogels Biomedical engineering |
| Zdroj: | Biomaterials Science Biomaterials Science, Royal Society of Chemistry (RSC), 2020, 8 (21), pp.5911-5919. ⟨10.1039/d0bm01535k⟩ Biomaterials Science, 2020, 8 (21), pp.5911-5919. ⟨10.1039/d0bm01535k⟩ |
| ISSN: | 2047-4849 |
| Popis: | A myriad of topical therapies and dressings are available to the clinicians for wound healing skin, but only a very few have shown their effectiveness in promoting wound repair due to challenges in controlling drug release. To address this issue, in this work, a near infrared (NIR)-light activable cryogel based on butyl methacrylate (BuMA) and poly(ethylene glycol) methyl ether methacrylate (PEGMEMA) incorporated with reduced graphene oxide (rGO) was fabricated. The obtained cryogel provides the required hydrophilicity beneficial for wound treatment. The excellent photo-thermal properties of rGO allow for heating the cryogel, which results in subsequent swelling of the cryogel (CG) followed by release of the encapsulated drug load, cefepime in our case. Without photothermal activation, no release of payload was observed. The potential of this bandage for wound healing was examined using an ex vivo human skin model infected with Staphylococcus aureus (S. aureus). Apart from the efficacy of the cryogel based wound healing system, our results also suggest that the ex vivo wound model evaluated here provides a rapid and valuable tool to study superficial skin infections in humans and test the efficacy of antimicrobial agents. |
| Databáze: | OpenAIRE |
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