Anti-viral potential of garlic (Allium sativum) and it's organosulfur compounds: A systematic update of pre-clinical and clinical data
| Autor: | Jamil A. Shilpi, Dipto Kumer Sarker, Satyajit D. Sarker, Razina Rouf, Evelin Tiralongo, Lutfun Nahar, Eunus S. Ali, Muhammad Torequl Islam, Shaikh Jamal Uddin |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway MARS-CoV Middle East respiratory syndrome coronavirus VV Vaccinia virus NA Not available AGE Aged garlic extract IAV-H1N1 IBV Influenza A virus-H1N1 Hp Haptoglobin Pharmacology AdV-41 Adenovirus-41 HPV Influenza B virus Human papillomavirus IEG1 Immediate-early gene 1 0302 clinical medicine IEGs Immediate-early genes NK Natural killer OSCs Organosulfur compounds MAPK Mitogen activated protein kinase Medicine CoV Coronavirus DDB Dimethyl-4 4′-dimethoxy-5 6 5′ 6′-dimethylene dioxybiphenyl-2 2′-dicarboxylate ECHO11 Echovirus-11 SAMC S-allyl-mercaptocysteine HCMV Human cytomegalovirus HRV-2 Human rhinovirus type 2 AdV-3 Adenovirus-3 Kinase RMCW Recalcitrant multiple common warts ERK Extracellular-signal-regulated kinase food and beverages MDCK cells Madin-darby canine kidney cells SI Selectivity index LGE Lipid garlic extract SAMG S-allyl-mercapto-glutathione SWV Spotted wilt virus SAC Serum antioxidant concentration 030220 oncology & carcinogenesis GRAS Generally regarded as safe Signal transduction RCTs Randomized clinical trials Allium sativum HSV-1 Herpes simplex virus-1 Biotechnology HIV-1 Human immunodeficiency virus-1 PGE Powdered garlic extract Immunomodulatory PRV Porcine Rotavirus Article ARVI Acute respiratory viral infection SARS-CoV Severe acute respiratory syndrome coronavirus CPE Cytopathic effect DADS Diallyl disulfide 03 medical and health sciences Immune system ECM Extracellular matrix Functional food Viral entry PVY Potato Virus Y HAV Hepatitis A virus AIV-H9N2 Avian influenza virus-H9N2 GLRaV‐2 Grapevine leafroll‐associated virus 2 Pandemic GO Garlic oil business.industry DAS Diallyl sulfide MeV Measles virus RV-SA-11 Rotavirus SA-11 ALT Alanine aminotransferase HSV-2 Herpes simplex virus-2 PRRSV Porcine reproductive and respiratory syndrome virus GE Garlic extract Reverse transcriptase PIV- 3 Parainfluenza virus-3 FDA Food and drug administration 030104 developmental biology NDV Newcastle disease virus VSV Vesicular stomatitis virus CBV-3 Coxsackie B −3 DATS Diallyl trisulfide business Food Science Organosulfur compounds SRGE Sustained release garlic extract |
| Zdroj: | Trends in Food Science & Technology |
| ISSN: | 1879-3053 0924-2244 |
| Popis: | Background Garlic (Allium sativum L.) is a common herb consumed worldwide as functional food and traditional remedy for the prevention of infectious diseases since ancient time. Garlic and its active organosulfur compounds (OSCs) have been reported to alleviate a number of viral infections in pre-clinical and clinical investigations. However, so far no systematic review on its anti-viral effects and the underlying molecular mechanisms exists. Scope and approach The aim of this review is to systematically summarize pre-clinical and clinical investigations on antiviral effects of garlic and its OSCs as well as to further analyse recent findings on the mechanisms that underpin these antiviral actions. PubMed, Cochrane library, Google Scholar and Science Direct databases were searched and articles up to June 2020 were included in this review. Key findings and conclusions Pre-clinical data demonstrated that garlic and its OSCs have potential antiviral activity against different human, animal and plant pathogenic viruses through blocking viral entry into host cells, inhibiting viral RNA polymerase, reverse transcriptase, DNA synthesis and immediate-early gene 1(IEG1) transcription, as well as through downregulating the extracellular-signal-regulated kinase (ERK)/mitogen activated protein kinase (MAPK) signaling pathway. The alleviation of viral infection was also shown to link with immunomodulatory effects of garlic and its OSCs. Clinical studies further demonstrated a prophylactic effect of garlic in the prevention of widespread viral infections in humans through enhancing the immune response. This review highlights that garlic possesses significant antiviral activity and can be used prophylactically in the prevention of viral infections. Highlights • Garlic have anti-viral and immune boosting properties. • Dietary intake of garlic and garlic products is suggested as a source of anti-viral agents that can prevent viral infections as a prophylactic intervention. • The organosulfur constituents of garlic contribute in prevention of viral infections. |
| Databáze: | OpenAIRE |
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