Pyoderma Gangrenosum with Ulcerative Colitis Successfully Treated by the Combination of Granulocyte and Monocyte Adsorption Apheresis and Corticosteroids
| Autor: | Fumiyasu Nakamura, Yu Kobayashi, Kazumi Shimamoto, Masashi Ohno, Shigeki Koyama, Kazuki Mitsuru, Mariko Ohara, Akira Andoh |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Prednisolone Granulocyte Gastroenterology Monocytes 03 medical and health sciences 0302 clinical medicine Adrenal Cortex Hormones Internal medicine Internal Medicine medicine Humans Leukapheresis medicine.diagnostic_test business.industry Monocyte General Medicine medicine.disease Ulcerative colitis Combined Modality Therapy Pyoderma Gangrenosum medicine.anatomical_structure Apheresis Treatment Outcome 030220 oncology & carcinogenesis Skin biopsy Blood Component Removal 030211 gastroenterology & hepatology Colitis Ulcerative Female business Pyoderma gangrenosum medicine.drug Granulocytes |
| Zdroj: | Internal medicine (Tokyo, Japan). 55(1) |
| ISSN: | 1349-7235 |
| Popis: | A 36-year-old woman was admitted to our hospital due to swelling and redness of the left lateral malleolus and dorsum of the left foot with severe pain, with a flare-up of ulcerative colitis (UC). A pathologic examination by skin biopsy led to a diagnosis of pyoderma gangrenosum (PG). She was treated with the intravenous administration of prednisolone (60 mg/day), and granulocyte and monocyte adsorption apheresis (GMA) was performed twice-a-week for 5 weeks. This treatment dramatically improved both the skin and colonic mucosal lesions. These results suggest that a combination of GMA and corticosteroids might be recommendable to induce the remission of serious PG complicated with UC. |
| Databáze: | OpenAIRE |
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