Effects and Safety of Herbal Medicines among Community-dwelling Residents during COVID-19 Pandemic: A Large Prospective, Randomized Controlled Trial (RCT)

Autor: Wang Jundong, Hai-Yan Li, Li-Na Wu, Xiaomo Xiong, Shi-Yun Tang, Hong Ding, Wenyuan Li, Minghui Li, Jing Yuan, Bo-Hua Yan, Z. Kevin Lu, Yu Shuguang, Zhi-Wei Jiang, Xiao-Ya Sang, Xie Hongyan, Jie-Lai Xia, Meng-Yao Tao, Chunguang Xie, Jian-Yuan Tang, Li Yan, Qiao-Ling Wang, Na Zhang, Jie-Ping Zeng
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Pharmaceutical Science
law.invention
0302 clinical medicine
Randomized controlled trial
law
Drug Discovery
Pandemic
Clinical endpoint
Prospective Studies
Abbreviations: Covid-19
coronavirus disease 2019
0303 health sciences
Coronavirus disease 2019
Common cold
Middle Aged
Treatment Outcome
030220 oncology & carcinogenesis
Molecular Medicine
Female
Original Article
ICD-11
International Statistical Classification of Diseases and Related Health Problems
Herbal medicine
Adult
China
medicine.medical_specialty
Adolescent
Coronavirus disease 2019 (COVID-19)
Respiratory tract infection
LMICs
low- and middle-income countries
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Young Adult
03 medical and health sciences
Intervention (counseling)
medicine
Humans
Pandemics
030304 developmental biology
Pharmacology
business.industry
Public health
COVID-19
Outbreak
medicine.disease
OR
odds ratio
Complementary and alternative medicine
Emergency medicine
WHO
World Health Organization
WHO
HAIs
hospital-acquired infections
business
ICTRP
International Clinical Trials Registry Platform
95%CI
95% confidence interval
CONSORT
Consolidated Standards of Reporting Trials
GEE
Generalized Estimation Equation
Drugs
Chinese Herbal
Zdroj: Phytomedicine
ISSN: 1618-095X
0944-7113
Popis: Highlights • This study is a community-based RCT. • This study provides scientific-based evidence on the effects and safety of herbal medicines during COVID-19 Pandemic.
Background : Since the declaration of COVID-19 as a global pandemic by the World Health Organization, countries are struggling with a shortage of medical capacities. It would be essential if the risk for preventable comorbidities, such as the common cold, can be reduced or prevented, so that the scarce medical resources and facilities can be focused on COVID-19. Purpose : To evaluate the effects of two herbal medicines (Jinhao artemisia antipyretic granules and Huoxiangzhengqi oral liquids) in reducing the risk of the common cold in community-dwelling residents in China during the COVID-19 outbreak. Study Design : An open-label, parallel-group, controlled, cluster-randomized trial, was conducted in Chengdu, China. Methods : A total of 22,065 participants from 11 communities were recruited during a period of 1 month. The trial started on 30 January and participants were followed up till 29 February 2020. Participants were randomly assigned to receive either a five-day herbal medicine therapy plus a reference manual for Health Infection Prevention and Control or the reference manual if they were allocated to the control group. The primary endpoint was the occurrence of patient-reported common cold symptoms. The secondary endpoint was the time in days from the receipt of herbal drugs/reference manual and the occurrence of the common cold symptoms. Results : Use of herbal medicine reduced the risk of the common cold by 89.6% (95% CI, 52.9% to 97.7%) in all community-dwelling residents, and by 94.0% (95% CI, 52.1% to 99.2%) in residents aged between 16 and 59 years old. Sensitivity analyses showed similar results. Conclusion : This community-based RCT found that the use of a herbal medicine therapy (Jinhao artemisia antipyretic granules and Huoxiangzhengqi oral liquids) could significantly reduce the risks of the common cold among community-dwelling residents, suggesting that herbal medicine may be a useful approach for public health intervention to minimize preventable morbidity during COVID-19 outbreak.
Databáze: OpenAIRE
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