The effect of acetazolamide on intra-ocular pressure after Trendelenburg positioning - a randomised double-blind crossover trial in volunteers
| Autor: | Boliang Guo, Austin G. Acheson, Charles Maxwell-Armstrong, P. Vitish-Sharma, Ali Abbas, Anthony J King |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Intraocular pressure medicine.medical_specialty genetic structures medicine.medical_treatment Trendelenburg position Trendelenburg positioning Placebo Head-Down Tilt 03 medical and health sciences 0302 clinical medicine Double-Blind Method 030202 anesthesiology Reference Values Medicine Humans 030212 general & internal medicine Diuretics Intraocular Pressure Cross-Over Studies business.industry Aqueous humour Middle Aged Crossover study eye diseases Colorectal surgery Healthy Volunteers Acetazolamide Anesthesiology and Pain Medicine Anesthesia Female business medicine.drug |
| Zdroj: | Anaesthesia. 72(12) |
| ISSN: | 1365-2044 |
| Popis: | Recent evidence suggests Trendelenburg positioning can produce a significant rise in intra-ocular pressure. Peri-operative vision loss in patients undergoing laparoscopic colorectal surgery has been reported with the rise in intra-ocular pressure suggested as a possible factor. Acetazolamide decreases intra-ocular pressure by reducing the formation of aqueous humour, so we aimed to investigate if it could attenuate the intra-ocular pressure rise that can occur in the Trendelenburg position. Nine healthy volunteers were recruited and randomly assigned to a double-blind crossover comparison of placebo or acetazolamide with a minimal 4 days' washout period before the second study day. One and a half hours after taking the medication, volunteers lay head-down at 17° for 4 h. Intraocular pressure measurements were repeated in both eyes every 30 min over a 4-h period. There were two males and seven female volunteers, with a mean (SD) age of 54.3 (18.5) years. The mean (SD) increase in intra-ocular pressure following 4 h in the Trendelenburg position was 3.17 (4.63) mmHg after the placebo, and 0.02 (4.01) mmHg (p = 0.02) after acetazolamide. We have shown than acetazolamide can attenuate the rise that occurs in intra-ocular pressure when in the Trendelenburg position. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text