Retinoids in Stellate Cells: Development, Repair, and Regeneration
| Autor: | Silvia Barrena, Ramón Muñoz-Chápuli, Rita Carmona |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
retinoids medicine.drug_class Angiogenesis Population Retinoic acid pancreatic ductal adenocarcinoma Review pancreatic stellate cells Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pancreatic cancer retinoic acid medicine tissue repair Retinoid Ito cells education lcsh:QH301-705.5 Molecular Biology education.field_of_study Regeneration (biology) Cell Biology medicine.disease 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) organ regeneration chemistry 030220 oncology & carcinogenesis Hepatocyte Hepatic stellate cell Cancer research hepatic stellate cells Developmental Biology |
| Zdroj: | Journal of Developmental Biology Journal of Developmental Biology, Vol 7, Iss 2, p 10 (2019) |
| ISSN: | 2221-3759 |
| DOI: | 10.3390/jdb7020010 |
| Popis: | Stellate cells, either hepatic (HSCs) or pancreatic (PSCs), are a type of interstitial cells characterized by their ability to store retinoids in lipid vesicles. In pathological conditions both HSCs and PSCs lose their retinoid content and transform into fibroblast-like cells, contributing to the fibrogenic response. HSCs also participate in other functions including vasoregulation, drug detoxification, immunotolerance, and maintenance of the hepatocyte population. PSCs maintain pancreatic tissue architecture and regulate pancreatic exocrine function. Recently, PSCs have attracted the attention of researchers due to their interactions with pancreatic ductal adenocarcinoma cells. PSCs promote tumour growth and angiogenesis, and their fibrotic activity increases the resistance of pancreatic cancer to chemotherapy and radiation. We are reviewing the current literature concerning the role played by retinoids in the physiology and pathophysiology of the stellate cells, paying attention to their developmental aspects as well as the function of stellate cells in tissue repair and organ regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|