The effect of environment on plasma cortisol and B-endorphin in the parturient pig and the involvement of endogenous opioids
| Autor: | SK Calvert, J Chirnside, KA McLean, Susan Jarvis, Alistair Lawrence, LA Deans |
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| Předmět: |
endocrine system
medicine.medical_specialty Hydrocortisone medicine.drug_class Swine animal diseases Gestational Age Environment chemistry.chemical_compound Endocrinology Food Animals Pregnancy Internal medicine medicine Animals Endorphins Endogenous opioid Labor Obstetric business.industry beta-Endorphin General Medicine Prolactin chemistry Vasopressin secretion Opioid Oxytocin Opioid Peptides Animal Science and Zoology Female business hormones hormone substitutes and hormone antagonists Opioid antagonist medicine.drug |
| Zdroj: | Scotland's Rural College |
| Popis: | Previous work has indicated that plasma cortisol increases during farrowing in the pig suggesting increasing physiological stress. The aim of this study was to determine changes in plasma cortisol and β-endorphin over farrowing in the pig to obtain a more detailed profile of pituitary and adrenal release at this time and also to investigate the involvement of endogenous opioids in the mediation of the HPA axis. Indwelling jugular catheters were implanted, under general anaesthesia, in 31 Large White×Landrace gilts approximately 15 days before the expected parturition day (EPD). Gilts were moved into either a farrowing crate, without straw ( n =15), or a straw-bedded pen ( n =16) 5 days before the EPD. Samples were taken during the pre-farrowing period and then during farrowing itself. At 7.5 min after the birth of the first piglet (BFP), gilts either received naloxone, an opioid antagonist, (1 mg kg −1 body weight, i.v.) or a control dose of saline. Plasma β-endorphin increased following the BFP but remained fairly constant over the third and fourth hour of farrowing. Plasma cortisol continued to increase over the 4 h following the BFP. Changes seen in these hormones were generally insensitive to the environment and there was little evidence of opioid mediation of the HPA axis at parturition. From these results it is suggested that certain aspect(s) of parturition itself stimulate the HPA axis. However it is unknown if the rise in plasma cortisol is a result of some stress-inducing factor of the parturition process or whether it reflects a metabolic function. The study also demonstrates the lack of any inhibitory mediation of the HPA axis by endogenous opioids at parturition. |
| Databáze: | OpenAIRE |
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