Dialkylaluminum N,O-dimethylhydroxylamine complex as a reagent to mask reactive carbonyl groups in situ from nucleophiles

Autor:	Francis J. Barrios, David A. Colby, Xuechao Zhang
Rok vydání:	2010
Předmět:	In situ Nucleophilic addition Alkylation Molecular Structure Chemistry Organic Chemistry N O-Dimethylhydroxylamine Biochemistry chemistry.chemical_compound Nucleophile Reagent Polymer chemistry Proton NMR Molecule Physical and Theoretical Chemistry Aluminum Compounds Dimethylamines
Zdroj:	Organic letters. 12(23)
ISSN:	1523-7052
Popis:	Aluminum complexes of N,O-dimethylhydroxylamine are effective reagents to mask carbonyl groups in situ from nucleophilic addition by organolithiums, Grignard reagents, and borohydrides. The utility of this process by selectively adding nucleophiles into carbonyl groups on a variety of structures as well as distinguishing between carbonyl groups on a sensitive natural product is demonstrated. (1)H NMR analysis supports the in situ masking of the more reactive carbonyl group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c7e04c3f3db94d7fbf0555070b1245 https://pubmed.ncbi.nlm.nih.gov/21038923 Zobrazit plný text záznamu