Cellular and molecular investigations into the development of the pectoral girdle
| Autor: | April DeLaurier, Yaniv Hinits, Helen Sang, Petr Valasek, Darrell J. R. Evans, Gavin Brooks, Bodo Christ, Susanne Theis, James E.N. Minchin, Ruijin Huang, Graham Luke, Anthony Otto, Liwen He, Malcolm Logan, Ketan Patel |
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| Rok vydání: | 2011 |
| Předmět: |
0106 biological sciences
Sternum Pectoral girdle Chick Embryo 01 natural sciences T-Box Domain Proteins/genetics Mice Scapula Forelimb Zebrafish 0303 health sciences Cleithrum Anatomy Muscle Skeletal/embryology Tbx5 Embryo Mammalian/metabolism Embryo Mammalian/cytology medicine.anatomical_structure Somites T-Box Domain Proteins/metabolism Muscle Forelimb/embryology animal structures Diaphragm Muscle Skeletal/anatomy & histology Somites/cytology Biology 010603 evolutionary biology Zebrafish/genetics Forelimb/cytology 03 medical and health sciences Limb bud medicine Animals Limb development Muscle Skeletal Molecular Biology Body Patterning 030304 developmental biology Shoulder girdle Cell Biology Embryo Mammalian body regions Muscle Skeletal/cytology Clavicle Zebrafish/embryology T-Box Domain Proteins Developmental Biology |
| Zdroj: | Valasek, P, Theis, S, DeLaurier, A, Hinits, Y, Luke, G N, Otto, A M, Minchin, J, He, L W, Christ, B, Brooks, G, Sang, H, Evans, D J, Logan, M, Huang, R J & Patel, K 2011, ' Cellular and molecular investigations into the development of the pectoral girdle ', Developmental Biology, vol. 357, no. 1, pp. 108-116 . https://doi.org/10.1016/j.ydbio.2011.06.031 |
| ISSN: | 0012-1606 |
| DOI: | 10.1016/j.ydbio.2011.06.031 |
| Popis: | The forelimbs of higher vertebrates are composed of two portions: the appendicular region (stylopod, zeugopod and autopod) and the less prominent proximal girdle elements (scapula and clavicle) that brace the limb to the main trunk axis. We show that the formation of the muscles of the proximal limb occurs through two distinct mechanisms. The more superficial girdle muscles (pectoral and latissimus dorsi) develop by the "In-Out" mechanism whereby migration of myogenic cells from the somites into the limb bud is followed by their extension from the proximal limb bud out onto the thorax. In contrast, the deeper girdle muscles (e.g. rhomboideus profundus and serratus anterior) are induced by the forelimb field which promotes myotomal extension directly from the somites. Tbx5 inactivation demonstrated its requirement for the development of all forelimb elements which include the skeletal elements, proximal and distal muscles as well as the sternum in mammals and the cleithrum of fish. Intriguingly, the formation of the diaphragm musculature is also dependent on the Tbx5 programme. These observations challenge our classical views of the boundary between limb and trunk tissues. We suggest that significant structures located in the body should be considered as components of the forelimb. (C) 2011 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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