The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic

Autor: Jung-Hyun Won, Howard Lee
Rok vydání: 2020
Předmět:
0301 basic medicine
medicine.medical_specialty
2019-20 coronavirus outbreak
COVID-19 Vaccines
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Review
public health crisis
Antiviral Agents
Catalysis
lcsh:Chemistry
Inorganic Chemistry
Antimalarials
03 medical and health sciences
0302 clinical medicine
vaccine
Pandemic
medicine
Humans
Protease Inhibitors
030212 general & internal medicine
Physical and Theoretical Chemistry
lcsh:QH301-705.5
Pandemics
Molecular Biology
Spectroscopy
SARS-CoV-2
business.industry
Public health
Organic Chemistry
Drug Repositioning
COVID-19
Chloroquine
Nucleosides
General Medicine
Public relations
COVID-19 Drug Treatment
Computer Science Applications
Knowledge sharing
Drug repositioning
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
Public Health
Business
Hydroxychloroquine
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 9775, p 9775 (2020)
ISSN: 1422-0067
DOI: 10.3390/ijms21249775
Popis: Since the outbreak of coronavirus disease 2019 (COVID-19) was first identified, the world has vehemently worked to develop treatments and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented speed. Few of the repositioned drugs for COVID-19 have shown that they were efficacious and safe. In contrast, a couple of vaccines against SARS-CoV-2 will be ready for mass rollout early next year. Despite successful vaccine development for COVID-19, the world will face a whole new set of challenges including scale-up manufacturing, cold-chain logistics, long-term safety, and low vaccine acceptance. We highlighted the importance of knowledge sharing and collaboration to find innovative answers to these challenges and to prepare for newly emerging viruses.
Databáze: OpenAIRE
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