Performance Characteristics of Adenoid Cystic Carcinoma of the Salivary Glands in Fine-Needle Aspirates: Results From the College of American Pathologists Nongynecologic Cytology Program
| Autor: | Alice Laser, Z. Laura Tabatabai, Rhona J. Souers, Barbara A. Crothers, Daniel F.I. Kurtycz, Güliz A. Barkan, Walid E. Khalbuss, Rodolfo Laucirica, Manon Auger |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Pathology Adenoid cystic carcinoma Concordance Biopsy Fine-Needle Malignancy Salivary Glands Pathology and Forensic Medicine Diagnosis Differential Cytology Biopsy medicine Carcinoma Humans False Negative Reactions Societies Medical Retrospective Studies Pathology Clinical Salivary gland medicine.diagnostic_test business.industry General Medicine Salivary Gland Neoplasms medicine.disease Carcinoma Adenoid Cystic United States Medical Laboratory Technology medicine.anatomical_structure Radiology Differential diagnosis business |
| Zdroj: | Archives of Pathology & Laboratory Medicine. 139:1525-1530 |
| ISSN: | 1543-2165 0003-9985 |
| DOI: | 10.5858/arpa.2013-0173-cp |
| Popis: | ContextAlthough the cytomorphology of adenoid cystic carcinoma (ACC) has been well described, the accuracy of this diagnosis in fine-needle aspirates (FNAs) of the salivary glands has not been extensively evaluated.ObjectiveTo assess participants' responses in the College of American Pathologists (CAP) Nongynecologic Cytology (NGC) Program to determine the accuracy and false-negative rate of ACC cases in salivary gland FNAs.DesignA retrospective review of the CAP NGC Program's cumulative data from 2000–2010 was performed for the general and the specific reference diagnosis categories for ACC in salivary gland FNAs according to preparation and participant types.ResultsOf 5156 responses, the overall concordance rates for both the general category of malignancy and the specific category of ACC were 63.6% (3279 of 5156) and 38.6% (1966 of 5088), respectively, with a false-negative rate of 36.4% (1877 of 5156). The most frequent false-negative responses were pleomorphic (1080) and monomorphic (526) adenoma (1614 of 5088, 31.5%), while lymphoma was the most frequent malignant misinterpretation. There was a significant statistical difference in concordance to the reference interpretation between the reader types: 39.9% (1006 of 2521) concordance rate for pathologists compared to 33.8% (503 of 1488) for cytotechnologists. However, there was no significant statistical difference for concordance to the general category or reference interpretation, based on preparation type (Papanicolaou versus modified Giemsa stained).ConclusionsIn this interlaboratory comparison educational program, accurate identification of ACC has shown to be problematic, with ACC representing an important cause of false-negative responses. The most common diagnostic pitfall is distinguishing this entity from pleomorphic and monomorphic adenoma in the benign category and from lymphoma and adenocarcinoma in the malignant one. |
| Databáze: | OpenAIRE |
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