Immune memory and immune response in children from Bulgaria 5-15 years after primary hepatitis B vaccination
| Autor: | Ani Kevorkyan, Ivan G. Baltadzhiev, Pavel Teoharov, Nedyalka S. Petrova, Pierre Van Damme |
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| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
Male Adolescent Immunization Secondary Immunological memory World health Statistics Nonparametric Immune system Infant vaccination Medicine Humans Hepatitis B Vaccines Hepatitis B Antibodies Bulgaria Child business.industry Hepatitis B medicine.disease Vaccination Infectious Diseases Immunization Hepatitis b vaccination Pediatrics Perinatology and Child Health Immunology Female Human medicine business Immunologic Memory |
| Zdroj: | The pediatric infectious disease journal |
| ISSN: | 1532-0987 0891-3668 |
| Popis: | Background: Bulgaria adopted the World Health Organization recommendation of routine universal infant vaccination against hepatitis B in 1991. Nevertheless, only a few studies evaluated the protection after the vaccination against hepatitis B, especially in children. The objective of this study was to investigate the duration of protection against hepatitis B in children aged 5-15 years after primary immunization, by measuring the immune and anamnestic immune response and possible breakthrough infections. Methods: A total of 141 children (aged 5-17 years) were recruited randomly and divided into 3 groups, approximately 5 years (group 1), 10 years (group 2) and 15 years (group 3) after primary immunization with a recombinant hepatitis B vaccine; they were tested for hepatitis B markers: hepatitis B surface antigen anti-hepatitis core antibody and antibodies to hepatitis B surface antigen (anti-HB). A booster dose of vaccine was administered to 23 children with titers of anti-HBs antibodies below the threshold considered to be protective (= 10 mIU/mL, and anti-hepatitis core antibodies were not detected. A booster dose of hepatitis B vaccine was administered to 23 of 45 (51%) children with anti-HBs |
| Databáze: | OpenAIRE |
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