Eight-year follow-up of airway hyperresponsiveness in patients with primary Sjögren's syndrome
| Autor: | S. Valtysdottir, Bjorn Gudbjornsson, Dora Ludviksdottir, Hans Hedenström, Roger Hällgren |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Longitudinal study Respiratory Medicine and Allergy Vital Capacity lcsh:Medicine Gastroenterology Diffusion 0302 clinical medicine follow-up Body Size Longitudinal Studies Lung Lung function Methacholine Chloride Lungmedicin och allergi medicine.diagnostic_test Follow up studies General Medicine Middle Aged respiratory system Respiratory Function Tests medicine.anatomical_structure Sjogren's Syndrome Sjogren's syndrome Female Spirometry medicine.medical_specialty Airway hyperresponsiveness Bronchial Provocation Tests 03 medical and health sciences stomatognathic system Internal medicine medicine Humans In patient Aged 030203 arthritis & rheumatology business.industry lcsh:R lung function Original Articles eye diseases respiratory tract diseases stomatognathic diseases 030228 respiratory system Sjögren’s syndrome Immunology Sjogren s business Follow-Up Studies |
| Zdroj: | Upsala Journal of Medical Sciences Upsala Journal of Medical Sciences, Vol 122, Iss 1, Pp 51-55 (2017) |
| Popis: | Objective: To evaluate in a longitudinal study the influence of airway hyperresponsiveness (AHR) on lung function in patients with primary Sjogren's syndrome (pSS). Methods: Lung function was studied over an eight-year period in 15 patients who fulfilled the Copenhagen criteria for primary Sjogren's syndrome and who were covered in our earlier published study on AHR in patients with Sjogren's syndrome. Standard spirometry and measurements of lung volumes, diffusing capacity (DLCO), and AHR to methacholine were performed. Results: A significant decline over time was found in total lung capacity (TLC), vital capacity (VC), forced vital capacity (FVC), functional residual capacity (FRC), and expiratory midflows (FEF50). A sign of small airway obstruction (decrease in FEF50) at entry correlated with VC at follow-up (r = .8, P < .003), and the individual change in FEF50 during the observation period correlated with the individual change in VC (r = .6, P < .05). Six patients had increased AHR, and three of them had decreased DLCO. Six of the patients progressively reduced DLCO over time, and five of them had spirometric signs of increased small airway obstruction. Conclusions: During this eight-year follow-up we observed that one-third of the patients with pSS developed a significant reduction in lung function. Our findings suggest that small airways obstruction and AHR are associated with reduction of VC and development of impaired DLCO as a sign of interstitial lung disease in this group of patients. |
| Databáze: | OpenAIRE |
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