Use of Statins Among Patients Taking Levothyroxine: an Observational Drug Utilization Study Across Sites
| Autor: | Julie K. Johnson, Wesley H. Prieto, Antonio C. Bianco, Matthew D Ettleson, Flavia A Andreotti Narchi, Sabina Casula, Aswathy Ajith, Anoop Mayampurath, Thaer Idrees, Rui M. B. Maciel, Pedro de Sá Tavares Russo, Fernando Fernandes |
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| Rok vydání: | 2021 |
| Předmět: |
Drug Utilization
endocrine system medicine.medical_specialty Statin medicine.drug_class Endocrinology Diabetes and Metabolism levothyroxine Levothyroxine 030209 endocrinology & metabolism Context (language use) statins thyroid 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine 030212 general & internal medicine Medical prescription Clinical Research Article business.industry cholesterol Odds ratio Clinical research Observational study hypothyroidism business AcademicSubjects/MED00250 medicine.drug |
| Zdroj: | Journal of the Endocrine Society |
| ISSN: | 2472-1972 |
| DOI: | 10.1210/jendso/bvab038 |
| Popis: | Context Treatment with levothyroxine (LT4) that normalize serum thyrotropin (TSH) is expected to restore lipid metabolism. Objective To assess statin utilization in LT4-treated patients through an observational drug utilization study. Methods Three sites were involved: (1) 10 723 outpatients placed on LT4 during 2006-2019 identified from the Clinical Research Data Warehouse of the University of Chicago; (2) ~1.4 million LT4 prescriptions prepared by primary care physicians during January-December 2018, identified from the IQVIA™ database of medical prescriptions in Brazil; (30 ~5.4 million patient interviews during 2009-2019, including ~0.32 million patients on LT4, identified from the Fleury Group database in Brazil. Results On site 1, initiation of therapy with LT4 increased the frequency of statin utilization (19.1% vs 24.6%), which occurred ~1.5 years later (median 76 weeks) and, among those patients that were on statins, increased intensity of treatment by 33%, despite normalization of serum TSH levels; on site 2, after matching for sex and age, the frequency of statins prescription was higher for those patients using LT4: females, 2.1 vs 3.4% (odds ratio [OR] 1.656 [1.639-1.673]); males, 3.1 vs 4.4% (OR 1.435 [1.409-1.462]); and, on site 3, after matching for sex and age, the frequency of statin utilization was higher in those patients using LT4: females, 10 vs 18% (OR 2.02 [2.00-2.04]); males, 15 vs 25% (OR 1.92 [1.88-1.96]); all P values were Conclusion Prescription and utilization of statins were higher in patients taking LT4. The reasons for this association should be addressed in future studies. |
| Databáze: | OpenAIRE |
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