Incidence of Lactic Acidosis in Patients With Type 2 Diabetes With and Without Renal Impairment Treated With Metformin: A Retrospective Cohort Study
| Autor: | Ulrike Gottwald-Hostalek, Frank A. Corvino, Meritxell Sabidó-Espin, Sandra Guedes, Florent F. Richy |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Databases Factual Endocrinology Diabetes and Metabolism Renal function Type 2 diabetes Gastroenterology Young Adult Diabetes mellitus Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Diabetic Nephropathies Renal Insufficiency Aged Retrospective Studies Aged 80 and over Advanced and Specialized Nursing Kidney business.industry Incidence Incidence (epidemiology) Retrospective cohort study Middle Aged medicine.disease Metformin United Kingdom Surgery medicine.anatomical_structure Diabetes Mellitus Type 2 Lactic acidosis Acidosis Lactic Female business Glomerular Filtration Rate medicine.drug |
| Zdroj: | Diabetes Care. 37:2291-2295 |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE To determine whether the use of metformin in type 2 diabetic patients with various kidney functions is associated with an increased risk of lactic acidosis (LA). RESEARCH DESIGN AND METHODS This study was a retrospective analysis of U.K. patient records from the Clinical Practice Research Datalink database from 1 January 2007 to 31 December 2012. Inclusion criteria were 1) diagnosis of type 2 diabetes before 1 January 2007, 2) treatment with metformin, and 3) at least one assessment of renal function between 2007 and 2012. Renal function was assessed by glomerular filtration rate and categorized as normal (N), mildly reduced (Mi), moderately reduced (Mo), or severely reduced (Se) function. The outcome of the study was LA. RESULTS A total of 77,601 patients treated with metformin for type 2 diabetes were identified. There were 35 LA events (10.37 [95% CI 7.22–14.42] per 100,000 patient-years) of which none were fatal and 23 were linked to a comorbidity. No significant difference in the incidence of LA was observed across N, Mi, Mo and Se renal function groups (7.6 [0.9–27.5], 4.6 [2.00–9.15], 17 [10.89–25.79], and 39 [4.72–140.89] cases per 100,000 patient-years, respectively). CONCLUSIONS The overall LA incidence rate for patients on metformin in this study was within the range of rates reported in the literature for patients with type 2 diabetes, and no significant difference was observed among patients with N, Mi, Mo, and Se function. |
| Databáze: | OpenAIRE |
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