CHANGES IN ADENOHYPOPHYSEAL CYTOLOGY AND NUCLEIC ACID CONTENT IN THE RAT 32 DAYS AFTER BILATERAL ADRENALECTOMY AND THE CHRONIC INJECTION OF CORTISOL
| Autor: | Pierre Duclos, Jacob Kraicer, Marc Herlant |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Pituitary gland Cell type Hydrocortisone Somatotropic cell Physiology medicine.medical_treatment Pituitary-Adrenal System Chromophobe cell Biology Prolactin cell Physiology (medical) Internal medicine medicine Animals Pharmacology Histocytochemistry Adrenalectomy Body Weight DNA General Medicine Rats Endocrinology medicine.anatomical_structure Pituitary Gland Protein Biosynthesis RNA Corticotropic cell hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Canadian Journal of Physiology and Pharmacology. 45:947-956 |
| ISSN: | 1205-7541 0008-4212 |
| DOI: | 10.1139/y67-112 |
| Popis: | Control, adrenalectomized, and cortisol-treated rats were maintained under rigidly controlled conditions, and the adenohypophyses were examined histologically with two staining procedures which differentiate six distinct cell types. Only one cell type demonstrated cytological evidence of increased synthetic activity 32 days after adrenalectomy (the changes were, however, minimal) and decreased synthetic activity following the chronic injection of cortisol. This cell type, which we designate as the corticotroph, would be classed as a chromophobe (no stainable granules) with use of standard histological techniques, but is, in fact, as Herlant's Tetrachrome demonstrates, a distinct acidophilic cell type different from the prolactin cell and the somatotroph. The determination of adenohypophyseal DNA and RNA revealed no evidence of increased protein synthetic activity following bilateral adrenalectomy, but did reveal evidence of decreased protein synthetic activity following the chronic injection of cortisol. |
| Databáze: | OpenAIRE |
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