Treatment of cytomegalovirus pneumonia with high-dose acyclovir
| Autor: | James D. Connor, James C. Wade, Robert W. McGuffin, Marie A. Hintz, Steven C. Springmeyer, Joel D. Meyers |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty Guanine Cytomegalovirus pneumonia Adolescent Pneumonia Viral Congenital cytomegalovirus infection Acyclovir Cytomegalovirus Bone Marrow Cells Antibodies Viral Lymphocyte Activation Antiviral Agents Nervous System Gastroenterology Internal medicine Case fatality rate medicine Humans Child Bone Marrow Transplantation biology business.industry Neurotoxicity virus diseases General Medicine medicine.disease Pneumonia Cytomegalovirus Infections Toxicity Immunology biology.protein Drug Evaluation Female Antibody Complication business |
| Zdroj: | The American Journal of Medicine. 73:249-256 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(82)90100-0 |
| Popis: | Cytomegalovirus pneumonia is a serious complication of marrow transplantation, with a 90 percent fatality rate. Acyclovir, a new antiviral agent with variable in vitro activity against cytomegalovirus, was administered to eight marrow transplant patients with biopsy-proven cytomegalovirus pneumonia; one patient survived. Doses were between 400 and 1200 mg/m2 and peak plasma levels between 47 and 316 microM were attained. Possible marrow toxicity occurred in three patients, and mild neurotoxicity occurred in one. High-dose acyclovir had mild toxicity but was not effective as treatment for cytomegalovirus pneumonia after marrow transplantation. |
| Databáze: | OpenAIRE |
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