Occurrence of vancomycin MIC creep in methicillin resistant isolates in Saudi Arabia
| Autor: | Jawaher Gramish, Salim Baharoon, Emad Masuadi, Bassam H Al Alwan, Sameerah Aljohani, Waleed Baharoon, Laila Layqah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
0301 basic medicine 030106 microbiology Saudi Arabia Microbial Sensitivity Tests MRSA Biology medicine.disease_cause Treatment failure Microbiology lcsh:Infectious and parasitic diseases 03 medical and health sciences Minimum inhibitory concentration 0302 clinical medicine medicine Humans lcsh:RC109-216 030212 general & internal medicine MIC creep lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 General Medicine Staphylococcal Infections biochemical phenomena metabolism and nutrition VANCOMYCIN Anti-Bacterial Agents Infectious Diseases Staphylococcus aureus Vancomycin Methicillin Resistance medicine.drug |
| Zdroj: | Journal of Infection and Public Health, Vol 13, Iss 10, Pp 1576-1579 (2020) |
| ISSN: | 1876-0341 |
| Popis: | Background “MIC creep” is a phenomenon that describes an increase of an organism MICs over time and have been reported from different parts of the world. High MIC in MRSA has been theoretically liked to treatment failure and may be a precursor to hVISA and VISA. This study was conducted to assess presence of vancomycin minimum inhibitory concentration (MIC) creeps among clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) in Saudi Arabia. Methods Minimum inhibitory concentration (MIC) of vancomycin by E test of all MRSA isolates of from 2013 to 2018 were reviewed. Results Of the 736 isolates evaluated, no isolates with MIC above 2 were found. Majority of MRSA isolates were susceptible to vancomycin with MIC less than 1. There was a significant increase in both Arithmetic and geometric mean MIC for vancomycin during the first three years which progressively declined in the next three years. Conclusions Although most of MRSA isolated remained very susceptible to vancomycin there was evidence of dynamic vancomycin MIC creep over time. |
| Databáze: | OpenAIRE |
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