Expression Patterns of Energy-Related Genes in Single Cells Uncover Key Isoforms and Enzymes That Gain Priority Under Nanoparticle-Induced Stress

Autor:	Fangjia Li, Hugh D. Mitchell, Arielle C. Mensch, Dehong Hu, Elizabeth D. Laudadio, Jenny K. Hedlund Orbeck, Robert J. Hamers, Galya Orr
Rok vydání:	2022
Předmět:	General Engineering Humans Nanoparticles Protein Isoforms General Physics and Astronomy General Materials Science Cobalt In Situ Hybridization Fluorescence
Zdroj:	ACS Nano. 16:7197-7209
ISSN:	1936-086X 1936-0851
Popis:	Cellular responses to nanoparticles (NPs) have been largely studied in cell populations, providing averaged values that often misrepresent the true molecular processes that occur in the individual cell. To understand how a cell redistributes limited molecular resources to achieve optimal response and survival requires single-cell analysis. Here we applied multiplex single molecule-based fluorescence
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b6d1d4dc5eef4c2545f3338e8ddc78 https://doi.org/10.1021/acsnano.1c08934 Zobrazit plný text záznamu