Neurosensory effects of chronic human exposure to arsenic associated with body burden and environmental measures
Autor: | J Telech, Y Li, J Prah, K Wu, Yajuan Xia, Timothy J. Wade, H Hundell, L He, J Mumford, David A. Otto |
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Rok vydání: | 2007 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Health Toxicology and Mutagenesis chemistry.chemical_element Urine Toxicology Vibration Arsenic 03 medical and health sciences 0302 clinical medicine Water Supply Environmental health Humans Medicine Child Neurologic Examination integumentary system 030102 biochemistry & molecular biology Arsenic toxicity business.industry Environmental Exposure Mongolia General Medicine Odds ratio Middle Aged Surgery Arsenic contamination of groundwater Nails chemistry Human exposure 030220 oncology & carcinogenesis Epidemiological Monitoring Toxicity Body Burden Female Nervous System Diseases business Risk assessment Water Pollutants Chemical Environmental Monitoring |
Zdroj: | Human & Experimental Toxicology. 26:169-177 |
ISSN: | 1477-0903 0960-3271 |
Popis: | Exposure to arsenic in drinking water is known to produce a variety of health problems, including peripheral neuropathy. Auditory, visual and somatosensory impairment have been reported in Mongolian farmers living in the Yellow River Valley, where drinking water is contaminated by arsenic. In the present study, sensory tests, including pinprick and vibration thresholds, were administered to 320 residents with well-water arsenic levels, ranging from non-detectable to 690 μg/L. Vibration thresholds in the second and fifth fingers of both hands were measured using a vibrothesiometer. Drinking water, urine and toenail samples were obtained to assess arsenic exposure and body burden. Regression analyses indicated significant associations of pinprick scores and vibration thresholds with all arsenic measures. Vibration thresholds were more strongly associated with urinary than water or nail arsenic measures, but odds ratios for decreased pinprick sensitivity were highest for the water arsenic measure. Results of the current study indicate neurosensory effects of arsenic exposure at concentrations well below the 1000 μg/L drinking water level specified by NRC, and suggest that non-carcinogenic end-points, such as vibration thresholds, are useful in the risk assessment of exposure to arsenic in drinking water. |
Databáze: | OpenAIRE |
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