Soft contact lens extended wear affects corneal epithelial permeability: hypoxic or mechanical etiology?
| Autor: | Carolin T. Lin, Gemma N. Soliman, Ying Q. Chen, J.Patrick Smith, Meng C. Lin, Kenneth A. Polse, Min J. Song |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Effects of long-term contact lens wear on the cornea genetic structures Chemistry Extended wear General Medicine Epithelial permeability Anatomy Eye Ophthalmology & Optometry Epithelium eye diseases Contact lens Ophthalmology medicine.anatomical_structure Permeability (electromagnetism) Opthalmology and Optometry Cornea medicine Epithelial barrier function sense organs Eye Disease and Disorders of Vision Optometry |
| Zdroj: | Contact Lens & Anterior Eye, vol 26, iss 1 Contact lens & anterior eye : the journal of the British Contact Lens Association, vol 26, iss 1 |
| Popis: | Contact lens extended wear increases the permeability of epithelium to sodium fluorescein (P(dc)). The exact mechanism is not known. However, changes in P(dc) likely result from either corneal hypoxia or mechanical trauma, or both. We explored the effects of one-night continuous wear with either high- or low-Dk/t soft lenses on P(dc). The results show that corneal epithelial barrier function decreases significantly with both lens groups. We also observed that Asian eyes had higher P(dc) after overnight wear compared to non-Asian and that for both Asian and non-Asian eyes, the elimination of corneal hypoxia did not prevent changes in epithelial permeability. |
| Databáze: | OpenAIRE |
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