Levels of Melatonin in Continuous Spikes and Waves During Sleep
| Autor: | Senem Ayça, Muzaffer Polat, Halil Ural Aksoy, İsmail Taştan |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Melatonin 03 medical and health sciences Epilepsy 0302 clinical medicine Internal medicine medicine Humans In patient Circadian rhythm Child Morning business.industry Electroencephalography medicine.disease Sleep in non-human animals Circadian Rhythm 030104 developmental biology Endocrinology Pediatrics Perinatology and Child Health Female Neurology (clinical) business Sleep 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of child neurology. 34(6) |
| ISSN: | 1708-8283 |
| Popis: | Levels of melatonin have been reported before in children with epilepsy, but such has not been reported to date in those with continuous spikes and waves during sleep. The aim of the present study was to assess serum melatonin levels and melatonin circadian rhythm in patients with continuous spikes and waves during sleep and epilepsy. Serum melatonin was measured in 39 children stratified into 3 groups. Group 1 included 15 patients with continuous spikes and waves during sleep, group 2 included 12 epilepsy patients, and group 3 included 12 controls, respectively. Blood samples were taken from all participants at 1:00 am and 9:00 am and melatonin levels were measured using a quantitative enzyme-linked immunosorbent assay test. The 9:00 am melatonin levels of group 1 were significantly decreased and pair groups were compared. The Pa value (representing a comparison between groups 1 and 2) was .002, the Pb value (representing a comparison between groups 1 and 3) was .001, and the Pc value (representing a comparison between groups 2 and 3) was .86. These findings suggest that the 9:00 am melatonin levels were significantly decreased in the comparison of groups 2 and 3. Further detailed research is necessary to determine the factors leading to the rapid decline of morning melatonin levels of children with continuous spikes and waves during sleep. |
| Databáze: | OpenAIRE |
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