Gadoxetate-enhanced Abbreviated MRI for Hepatocellular Carcinoma Surveillance: Preliminary Experience
| Autor: | Bachir Taouli, Naik Vietti Violi, Robert M. Marks, Ryan L. Brunsing, Dennis H. Chen, Claude B. Sirlin, Adrija Mamidipalli, Anthony Gamst, Yuko Kono, Tanya Wolfson, Rohit Loomba, Alexandra Schlein |
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| Rok vydání: | 2019 |
| Předmět: |
Liver Cancer
Adult Gadolinium DTPA Liver Cirrhosis Male medicine.medical_specialty Carcinoma Hepatocellular Chronic Liver Disease and Cirrhosis Contrast Media Sensitivity and Specificity Hepatitis Rare Diseases Text mining Hepatitis B Chronic Clinical Research Medicine Humans Chronic Cancer Retrospective Studies Original Research screening and diagnosis business.industry Liver Disease Carcinoma fungi Liver Neoplasms food and beverages Hepatocellular General Medicine Middle Aged Reference Standards Hepatitis B medicine.disease Image Enhancement Magnetic Resonance Imaging Detection Good Health and Well Being Hepatocellular carcinoma Biomedical Imaging Female Radiology Digestive Diseases business 4.2 Evaluation of markers and technologies Preliminary Data |
| Zdroj: | Radiol Imaging Cancer Radiology. Imaging cancer, vol 1, iss 2 |
| ISSN: | 2638-616X |
| Popis: | PURPOSE: To describe a single-center preliminary experience with gadoxetate disodium–enhanced abbreviated MRI for hepatocellular carcinoma (HCC) screening and surveillance in patients with cirrhosis or chronic hepatitis B virus (cHBV). MATERIALS AND METHODS: This was a retrospective study of consecutive patients aged 18 years and older with cirrhosis or cHBV who underwent at least one gadoxetate-enhanced abbreviated MRI examination for HCC surveillance from 2014 through 2016. Examinations were interpreted prospectively by one of six abdominal radiologists for clinical care. Clinical, imaging, and other data were extracted from electronic medical records. Diagnostic adequacy was assessed in all patients. Diagnostic accuracy was assessed in the subset of patients who could be classified as having HCC or not having HCC on the basis of a composite reference standard. RESULTS: In this study, 330 patients (93% with cirrhosis; 45% women; mean age, 59 years) underwent gadoxetate-enhanced abbreviated MRI. In the 330 patients, 311 (94.2%) baseline gadoxetate-enhanced abbreviated MRI examinations were diagnostically adequate. Of 141 (43%) of the 330 patients, 91.4% (129 of 141) could be classified as not having HCC and 8.6% (12 of 141) could be classified as having HCC. Baseline gadoxetate-enhanced abbreviated MRI had 0.92 sensitivity (95% confidence interval [CI]: 0.62, 1.00) and 0.91 specificity (95% CI: 0.84, 0.95) for detection of HCC. Of the 330 patients who underwent baseline gadoxetate-enhanced abbreviated MRI, 187 (57%) were lost to follow-up. CONCLUSION: Gadoxetate-enhanced abbreviated MRI is feasible clinically, has a high diagnostic adequacy rate, and, on the basis of our preliminary experience, accurately depicts HCC in high-risk patients. Strategies to enhance follow-up compliance are needed. © RSNA, 2019 Keywords: Abdomen/GI, Cirrhosis, Liver, MR-Imaging, Oncology, Screening Supplemental material is available for this article. |
| Databáze: | OpenAIRE |
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