Into and out of G1: The control of cell proliferation

Autor:	S. Tiwari, N.S.B. Thomas, R.H. Charollais
Rok vydání:	1994
Předmět:	Cyclin E biology Cyclin D Cyclin A G1 Phase Retinoblastoma protein General Medicine Cell cycle Biochemistry Cell biology Cyclin-dependent kinase biology.protein Animals Humans Cell Division Cyclin A2 Cyclin
Zdroj:	Biochimie. 76:887-894
ISSN:	0300-9084
DOI:	10.1016/0300-9084(94)90191-0
Popis:	Progression of cells through G1 is an orderly process which is regulated by a series of key proteins. Over the past few years a number of these proteins have been identified and their mode of action has been studied in detail. This review will concentrate on the current knowledge about the function in G1 of cyclins, cyclin dependent kinases, the retinoblastoma protein and other related 'pocket' proteins. Mutations or deregulation of some of these proteins confer a growth advantage and their role in malignant transformation will be discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b3a1917033d5eb221921c35c64ec96 https://doi.org/10.1016/0300-9084(94)90191-0 Zobrazit plný text záznamu