Comparing sequential vs day 3 vs day 5 embryo transfers in cases with recurrent implantation failure: randomized controlled trial
| Autor: | Rania Aly, El-Sayed El-Desouky, Haitham Torky, Mona Ragab, Ali M. Ahmad, Ashraf Abo-Louz, Ahmed Hussein |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
sequential transfer Pregnancy Rate Cleavage Stage Ovum Clinical pregnancy Fertilization in Vitro law.invention Implantation failure Randomized controlled trial law Recurrent implantation failure Pregnancy medicine Humans Prospective Studies business.industry Blastocyst Transfer Obstetrics and Gynecology Embryo Blastocyst transfer Embryo Transfer Sequential media Embryo transfer Surgery consecutive transfer Implantation rate Blastocyst embryonic structures Original Article Female Live birth business |
| Zdroj: | JBRA Assisted Reproduction |
| ISSN: | 1518-0557 |
| Popis: | Objective The recent improvement in sequential media has refocused its attention on the role of human blastocysts in ART, not only because of its advantages but also because of the possible cancellation of embryo transfer when relying on blastocyst transfer only. Hence, the idea of sequential transfer on day 3 and day 5 was proposed. Objective: To compare the pregnancy outcomes of sequential embryo transfer on day 3 and day 5, versus cleavage transfer on day 3 and blastocyst transfer on day 5 in cases of recurrent implantation failure. Methods This was a prospective and randomized trial, in which 210 qualified patients with recurrent implantation failures undergoing IVF/ICSI were randomized into three groups, each group included 70 patients. Embryo transfer was performed in day 3 in the first group, day 5 (blastocyst transfer) in the second group and sequential embryo transfer in days 3 and 5 in the third group. We assessed pregnancy outcomes from all the three groups. Results: Clinical pregnancy and live birth rates were significantly higher in the sequential group than either group day-3 or day-5 of embryo transfer in cases with recurrent implantation failures. Conclusions Sequential embryo transfer in cases with recurrent implantation failures and adequate number of retrieved oocytes is associated with higher implantation and clinical pregnancy rates, and it is advocated for patients having an adequate number of good quality embryos. |
| Databáze: | OpenAIRE |
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