Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis
| Autor: | I C Abbs, Maria José Cuadrado, G. R. V. Hughes, Luís Bento, Muhammad Tungekar, Munther A. Khamashta, P Alba, David D'Cruz, Yousuf Karim |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Statistics as Topic Lupus nephritis Black People Gastroenterology Autoantigens General Biochemistry Genetics and Molecular Biology snRNP Core Proteins Nephropathy Rheumatology immune system diseases Risk Factors Internal medicine medicine Immunology and Allergy Humans Lupus Erythematosus Systemic Risk factor skin and connective tissue diseases Autoantibodies Retrospective Studies Lupus anticoagulant Lupus erythematosus Systemic lupus erythematosus SnRNP Core Proteins business.industry Age Factors DNA Middle Aged medicine.disease Ribonucleoproteins Small Nuclear Lupus Nephritis Extended Report Antibodies Antinuclear Case-Control Studies Lupus Coagulation Inhibitor Female business Nephritis Biomarkers |
| Zdroj: | Annals of the rheumatic diseases. 62(6) |
| ISSN: | 0003-4967 |
| Popis: | Background: Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial. Objective: To study the immunological and demographic factors associated with the development of LN. Patients and methods: A retrospective case-control study of 127 patients with biopsy-proven LN, and 206 randomly selected patients with SLE without nephritis as controls was designed. All patients had attended our lupus unit during the past 12 years. Standard methods were used for laboratory testing. Results: Patients with LN were significantly younger than the controls at the time of SLE diagnosis (mean (SD) 25.6 (8.8) years v 33.7 (12.5) years; p |
| Databáze: | OpenAIRE |
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