Live donor kidney transplantation in India: effects of donor and recipient age on graft survival
| Autor: | Arun Chawla, Harsh Jauhari, Sudhir Chadha, Yusuf Saifee, Vipin Tyagi, Tanveer Iqbal Dar, Archna R. Pahwa, Mrinal Pahwa |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Graft Rejection medicine.medical_specialty Live donor India Primary Graft Dysfunction Kaplan-Meier Estimate Critical Care and Intensive Care Medicine Expanded Criteria Donor Donor age Living Donors medicine Humans Kidney transplantation Aged Retrospective Studies business.industry Graft Survival Age Factors Retrospective cohort study General Medicine Middle Aged Allografts medicine.disease Kidney Transplantation Surgery Nephrology Creatinine Renal allograft Kidney Failure Chronic Graft survival business |
| Zdroj: | Renal Failure. 36:222-224 |
| ISSN: | 1525-6049 0886-022X |
| DOI: | 10.3109/0886022x.2013.846795 |
| Popis: | The increasing gap between demand and supply of human kidneys has resulted in the use of more expanded criteria donor organs are used. The influence of age on short- and long-term survival of renal allograft has not been well studied in Indian population.Two hundred and seventy-eight patients were evaluated retrospectively who underwent kidney transplantation from Jan 2008 to June 2011. Patients were divided into 6 groups: group A (donor age 20-40 years, recipient age50 years), group B (donor age 20-40 years, recipient age50 years), group C (donor age 40-60 years, recipient age50 years), group D (donor age 40-60 years, recipient age50 years), group E (donor age60 years, recipient age50 years) and group F (donor age60 years, recipient age50 years). Uni-variate analysis was used to assess the effect of donor and recipient age as predictive factors for graft outcome, using the Kaplan-Meier method (log-rank) with p 0.05 considered significant.Graft survival was found to be lowest in elderly recipients and in patients with donor age60 years. Renal function was superior using younger donors both in short and long term. The incidence of acute rejection was found to be lower in elderly donor group than in younger, although the difference was not statistically significant.Donor's higher age did not show significant impact on allograft survival although, kidney allografts demonstrated decreased short and long term renal function. |
| Databáze: | OpenAIRE |
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