New perspectives on cytokine pathways modulation by pesticide exposure
| Autor: | Concettina Fenga, Giusi Briguglio, Michele Teodoro, Federica Giambò, Chiara Costa, Rosaria Catanoso, Irene Polito |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Inflammation Immunotoxicology 010501 environmental sciences Toxicology 01 natural sciences Proinflammatory cytokine 03 medical and health sciences Immune system Cytokine pathways Immune system Occupational exposure Pesticides Medicine Epigenetics Pesticides 0105 earth and related environmental sciences Innate immune system business.industry Cytokine pathways Environmental exposure Occupational exposure 030104 developmental biology Cytokine Immunology medicine.symptom business |
| Zdroj: | Current Opinion in Toxicology. 19:99-104 |
| ISSN: | 2468-2020 |
| DOI: | 10.1016/j.cotox.2020.01.002 |
| Popis: | Immune cells are able to release a variety of inflammation mediators, activating proinflammatory and antiinflammatory processes and regulating intracellular pathways. Consequences of chronic or early-life exposure to pesticides may be extended beyond innate immune dysfunction to the increased risk of late-life chronic inflammatory-based diseases. This study aims to summarize some of the most recent advancements in occupational toxicology, focusing on biological mechanisms linking environmental exposure to pesticides, inflammation, and cytokine modulation, as well as genetic polymorphisms or epigenetic modifications which can represent factors of vulnerability for exposed workers. Choosing appropriate toxicity biomarkers is also one of the main concerns in the field of immunotoxicology; for this purpose, new technologies have been introduced for the monitoring of pesticides blood levels along with molecular alterations. These approaches will allow the assessment of the actual body burden of environmental pollutants associating it with a screening for the early diagnosis of pathologies. |
| Databáze: | OpenAIRE |
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