Antioxidant status of hypercholesterolemic patients treated with LDL apheresis
| Autor: | Brigitte Bourely, M C Jaudon, Eric Bruckert, Ubald Assogba, Dominique Bonnefont-Rousselot, Sylvie Lepage, Jacques Delattre |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Vitamin
Adult Male medicine.medical_specialty Antioxidant medicine.medical_treatment Hypercholesterolemia chemistry.chemical_element Antioxidants chemistry.chemical_compound Internal medicine medicine Humans Pharmacology (medical) Pharmacology chemistry.chemical_classification business.industry Vitamin E Glutathione peroxidase General Medicine Cholesterol LDL Vitamins Trace Elements Endocrinology Apheresis Cholesterol chemistry LDL apheresis Low-density lipoprotein Blood Component Removal Female Cardiology and Cardiovascular Medicine business Selenium |
| Zdroj: | Cardiovascular drugs and therapy. 10(5) |
| ISSN: | 0920-3206 |
| Popis: | Oxidation of low density lipoprotein is involved in the pathogenesis of atherosclerosis. Epidemiological studies suggest a negative correlation between the occurrence of cardiovascular diseases and blood concentrations of lipophilic antioxidants such as vitamins A and E and beta-carotene. Trace elements, such as selenium, zinc, and copper, are involved in the activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. The aim of this study was to determine the antioxidant and trace element status of patients with severe hypercholesterolemia who had been treated with dextran-sulphate low-density lipoprotein apheresis in comparison with two control populations, normocholesterolemic subjects and untreated hypercholesterolemic patients. Our results showed that, patients treated with LDL apheresis, compared with normocholesteromic subjects, were not deficient in vitamin E, beta-carotene, and copper, but had lower plasma levels of selenium, zinc, and vitamin A. The low selenium and vitamin A levels were due to the LDL-apheresis treatment, and the hypercholesterolemia might have provoked the low plasma levels of zinc. The study pointed out the potential benefits of supplemental selenium, zinc, and vitamin A in patients being treated with LDL apheresis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink