Childhood BMI and Fasting Glucose and Insulin Predict Adult Type 2 Diabetes: The International Childhood Cardiovascular Cohort (i3C) Consortium
| Autor: | Stephen R. Daniels, Elaine M. Urbina, Trudy L. Burns, David R. Jacobs, Jessica G. Woo, Nina Hutri-Kähönen, Terry Dwyer, Tian Hu, Markus Juonala, Kari Murdy, Lydia A. Bazzano, Alison Venn, Alan R. Sinaiko, Ronald J. Prineas, Julia Steinberger, Olli T. Raitakari |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male Research design Cardiovascular and Metabolic Risk Percentile Pediatrics medicine.medical_specialty endocrine system diseases Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Body Mass Index Fasting glucose Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Diabetes mellitus Internal Medicine Humans Insulin Medicine 030212 general & internal medicine Child Normal range Advanced and Specialized Nursing business.industry Incidence nutritional and metabolic diseases Fasting Middle Aged medicine.disease Health Surveys Diabetes Mellitus Type 2 Child Preschool Cohort Female Self Report Adult type business Follow-Up Studies |
| Zdroj: | Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| Popis: | OBJECTIVE To examine childhood BMI, fasting glucose, and insulin in relation to incident adult type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS We used data from the International Childhood Cardiovascular Cohort (i3C) Consortium. Data included childhood (age 3–19 years) measurements obtained during the 1970s–1990s; a health questionnaire, including self-report of adult T2DM (occurrence age, medication use) obtained at mean age 40 years; and a medical diagnosis registry (Finland). RESULTS The sample included 6,738 participants. Of these, 436 (6.5%) reported onset of T2DM between ages 20 and 59 (mean 40.8) years, and 86% of them reported use of a confirmed antidiabetic medication. BMI and glucose (age and sex standardized) were associated with incident T2DM after adjustment for cohort, country, sex, race, age, and calendar year of measurement. Increasing levels of childhood BMI and glucose were related to an incrementally increased risk of T2DM beginning at age 30 years, beginning at cut points CONCLUSIONS Childhood BMI and glucose are predictors of adult T2DM at levels previously considered to be within the normal range. These easy-to-apply measurements are appealing from a clinical perspective. Fasting insulin has the potential to be an additional predictor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|