Pathogenesis of superficial mycoses
| Autor: | H. Ogawa, I. Takaiuchi, A. Nakabayashi, G. S. Shankland, Ryoji Tsuboi, J. Ninomiya, Kusmarinah Bramono, C. D. Payne, Malcolm Richardson, Y. Sei, W. J. Crozier, T. L. Ray |
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| Předmět: |
Keratinocytes
Microsporum species Molecular Sequence Data Skin infection Microbiology Pathogenesis Mice Trichophyton Candida albicans Endopeptidases Cell Adhesion medicine Animals Aspartic Acid Endopeptidases Dermatomycoses Humans Amino Acid Sequence Mycosis Mice Inbred BALB C Corneocyte biology General Medicine biology.organism_classification medicine.disease Infectious Diseases Arthroconidium |
| Zdroj: | Europe PubMed Central |
| Popis: | Detailed understanding of the pathogenesis of common superficial mycoses remains elusive. Modern technology now permits innovative studies to address biochemical and molecular mechanisms involved in the development of cutaneous fungal infections. These events are now being dissected on a broad front that involves numerous organisms and diseases. Only a few of these efforts can be included in this symposium, but they are representative of the types of studies being done to elucidate the pathogenic mechanisms of superficial mycoses. The reports exemplify the approaches to several issues that are perceived to be central to early pathological events in cutaneous fungal infections. These include adherence of fungal elements to corneocytes and keratinocytes of the epidermis, colonization of the stratum corneum and maintenance of germinating arthroconidia to perpetuate the infection process. Specific enzymatic activities from Candida and Microsporum species are discussed as proposed or putative virulence factors and their specific roles in skin infections are examined. The adaptation of fungal species to specific sites and types of infections is also presented. Students of cutaneous mycology will hopefully find in this symposium the seeds for new projects and studies. |
| Databáze: | OpenAIRE |
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