Telomere Biology and Thoracic Aortic Aneurysm
| Autor: | Thomas Aschacher, Florian K. Enzmann, Barbara Messner, Michael Bergmann, O. Salameh |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Senescence Telomerase Aging Perforation (oil well) Review Bioinformatics telomerase Thoracic aortic aneurysm Catalysis lcsh:Chemistry Inorganic Chemistry 03 medical and health sciences Aortic aneurysm Mice Risk Factors medicine.artery Ascending aorta medicine Animals Humans Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Spectroscopy Telomere Shortening Aortic dissection telomere maintenance mechanism Aortic Aneurysm Thoracic business.industry Organic Chemistry General Medicine DNA Telomere medicine.disease telomeres Computer Science Applications Rats 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 cardiovascular system business aortic aneurysm Biomarkers |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 19, Iss 1, p 3 (2017) |
| ISSN: | 1422-0067 |
| Popis: | Ascending aortic aneurysms are mostly asymptomatic and present a great risk of aortic dissection or perforation. Consequently, ascending aortic aneurysms are a source of lethality with increased age. Biological aging results in progressive attrition of telomeres, which are the repetitive DNA sequences at the end of chromosomes. These telomeres play an important role in protection of genomic DNA from end-to-end fusions. Telomere maintenance and telomere attrition-associated senescence of endothelial and smooth muscle cells have been indicated to be part of the pathogenesis of degenerative vascular diseases. This systematic review provides an overview of telomeres, telomere-associated proteins and telomerase to the formation and progression of aneurysms of the thoracic ascending aorta. A better understanding of telomere regulation in the vascular pathology might provide new therapeutic approaches. Measurements of telomere length and telomerase activity could be potential prognostic biomarkers for increased risk of death in elderly patients suffering from an aortic aneurysm. |
| Databáze: | OpenAIRE |
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