CC-chemokines enhance the replication of T-tropic strains of HIV-1 in CD4(+) T cells: role of signal transduction
| Autor: | Jesse S. Justement, Susan Moir, Andrew T. Catanzaro, Robert W. Jackson, Linda A. Ehler, James Arthos, JoAn Monaco, Stephanie B. Mizell, Alessandra Oliva, Audrey Kinter, Mario A. Ostrowski, Margaret Ruiz, James A. Hoxie, Robin E. Offord, Anthony S. Fauci |
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| Rok vydání: | 1998 |
| Předmět: |
CD4-Positive T-Lymphocytes
Cell signaling Receptors CXCR4 Anti-HIV Agents T cell viruses Cell HIV Infections Biology CD8-Positive T-Lymphocytes In Vitro Techniques Virus Replication CXCR4 GTP-binding protein regulators GTP-Binding Proteins HIV Seronegativity medicine Humans Chemokine CCL5 Multidisciplinary virus diseases Biological Sciences Virology Cell biology medicine.anatomical_structure Viral replication Chemokines CC CD4 Antigens HIV-1 Signal transduction Signal Transduction |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 95(20) |
| ISSN: | 0027-8424 |
| Popis: | This study demonstrates that several CC-chemokines, including those that inhibit entry and replication of macrophage-tropic strains of HIV, increase the replication of T cell (T)-tropic strains in CD4+T cells. Enhancement of T-tropic HIV replication is observed at early stages of replication, requires signaling through inhibitory guanine nucleotide-binding regulatory (Gi) proteins, and is associated with increased cell surface colocalization of CD4 and the T-tropic HIV coreceptor CXCR4. These findings may further our understanding of the factors that influence the replication and spread of T-tropic strains of HIVin vivoand suggest that the use of cell signaling CC-chemokines as therapeutic agents for the purpose of limiting HIV replicationin vivoshould be approached with caution. |
| Databáze: | OpenAIRE |
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