Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics
| Autor: | Veronika Müller, G. Losonczy, Anikó Bohács, Lilla Tamási, Zsolt István Komlósi, András Falus, Éva Pállinger, János Rigó, Pál Magyar |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Allergy Pregnancy Trimester Third T-Lymphocytes medicine.medical_treatment Immunology Peak Expiratory Flow Rate Interferon-gamma Th2 Cells Pregnancy medicine Birth Weight Humans Immunology and Allergy Interferon gamma Lymphocyte Count Lung Asthma Fetus business.industry Infant Newborn T lymphocyte Th1 Cells Flow Cytometry medicine.disease Pregnancy Complications Cytokine Case-Control Studies Pregnancy Trimester Second Linear Models Gestation Female Interleukin-4 business medicine.drug |
| Zdroj: | Clinical Experimental Allergy. 35:1197-1203 |
| ISSN: | 1365-2222 0954-7894 |
| DOI: | 10.1111/j.1365-2222.2005.02322.x |
| Popis: | Summary Background Pregnancy frequently interferes with the course of bronchial asthma, and asthmatic pregnant women experience less successful pregnancies. T lymphocytes synthesizing IL-4 or IFN-γ are important in allergic mechanisms of the airways as well as in materno-fetal immunity. Objective We hypothesized that pregnancy (a T helper-2 polarized state) of asthmatics will enhance the number of circulating T2 lymphocytes, but decrease the subset-producing IFN-γ (T1 lymphocytes) and thereby cause a culminating T2 dominance with possible clinical consequences. Methods IL-4- or IFN-γ-producing T lymphocytes were determined by flow cytometry in healthy (n=8) and asthmatic (n=13) non-pregnant women and healthy (n=18) and asthmatic (n=48) pregnant women of similar chronological and gestational (2nd–3rd trimester) age and asthma severity (Global Initiative for Asthma II–III). Results In the blood of non-pregnant women – healthy or asthmatic – the numbers of IL-4- and IFN-γ+ T cells were very low ( |
| Databáze: | OpenAIRE |
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