How inhibitory neurons increase information transmission under threshold modulation
| Autor: | Tatyana O. Sharpee, Wei-Mien M. Hsu, Stephen A. Baccus, David B. Kastner |
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| Rok vydání: | 2021 |
| Předmět: |
Neurons
0301 basic medicine Neurotransmitter Agents Retina Cell type Biology Stimulus (physiology) Inhibitory postsynaptic potential Synaptic Transmission Anticipation General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure nervous system Modulation Neuromodulation medicine Humans Neuron Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports. 35:109158 |
| ISSN: | 2211-1247 |
| Popis: | Modulation of neuronal thresholds is ubiquitous in the brain. Phenomena such as figure-ground segmentation, motion detection, stimulus anticipation, and shifts in attention all involve changes in a neuron's threshold based on signals from larger scales than its primary inputs. However, this modulation reduces the accuracy with which neurons can represent their primary inputs, creating a mystery as to why threshold modulation is so widespread in the brain. We find that modulation is less detrimental than other forms of neuronal variability and that its negative effects can be nearly completely eliminated if modulation is applied selectively to sparsely responding neurons in a circuit by inhibitory neurons. We verify these predictions in the retina where we find that inhibitory amacrine cells selectively deliver modulation signals to sparsely responding ganglion cell types. Our findings elucidate the central role that inhibitory neurons play in maximizing information transmission under modulation. |
| Databáze: | OpenAIRE |
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