Acute oral toxicity of a novel functional drink based on Ilex guayusa, Vernonanthura patens, and cocoa husk
| Autor: | Glenda Pilozo, Geovanna Paladines-Santacruz, Patricia Manzano, Davide Di Grumo, Silvia Orellana-Manzano, Fausto Zaruma-Torres, María Quijano-Avilés, María del Carmen Villacrés, Johana Ortíz-Ulloa, Glenda Sarmiento, Andrea Orellana-Manzano, Elsy Iñiga, Wim Vanden Berghe |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
Acute oral toxicity Health Toxicology and Mutagenesis medicine.medical_treatment Cocoa husk 010501 environmental sciences Vernonanthura patens Toxicology 01 natural sciences Husk 03 medical and health sciences Mice 0302 clinical medicine Nutraceutical RA1190-1270 medicine Oral toxicity Biology 0105 earth and related environmental sciences biology Traditional medicine business.industry Pharmacology. Therapy biology.organism_classification Functional drink Stimulant Ilex guayusa Toxicity Toxicology. Poisons Human medicine business 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports, Vol 8, Iss, Pp 747-752 (2021) Toxicology Reports |
| ISSN: | 2214-7500 |
| Popis: | A novel functional drink with nutraceutical properties was formulated from the aqueous extracts of Ilex guayusa, and Vernonanthura patens leaves, and cocoa husks. This juice contains various bioactive compounds, such as phenolic compounds and methylxanthines, with antioxidant and stimulant properties of pharmacological interest. However, it is known whether herbal extracts' interaction may have adverse toxic effects on human health. To evaluate this functional drink's innocuity, we estimated the acute oral toxicity (AOT) in experimental mice. This paper presents the AOT evaluation of two formulations of a functional drink (pre-formulation and microencapsulation) at a single dose of 2000 mg/kg of body weight (b.w.). No signs of adverse toxicity and mortality were observed after a single oral dose of 2000 mg/kg b.w. Likewise, no significant body and organ weight changes, food and water consumption behavior, and no histopathological changes were observed in the main organs evaluated. In conclusion, this functional drink can be categorized as low toxicity " according to the Globally Harmonized Classification System (GHS), making it a potential beverage with high nutritional and pharmacological value. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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