T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines

Autor: Smina Ait-Yahia, François Fossiez, Claude Gaillard, Eric Garcia, C Maat, B Das Mahapatra, Jean-Jacques Pin, Leopoldo Flores-Romo, E Rouvier, Pierre Golstein, Sem Saeland, Pierre Garrone, Odile Djossou, D Blanchard, Jacques Banchereau, Serge Lebecque, Pascale Chomarat
Rok vydání: 1996
Předmět:
T-Lymphocytes
Arthritis
Rheumatoid
Mice
Reference Values
Granulocyte Colony-Stimulating Factor
Immunology and Allergy
Cytotoxic T cell
Lymphocytes
Skin
Interleukin-17
Synovial Membrane
Interleukin
Articles
Recombinant Proteins
Cell biology
medicine.anatomical_structure
Cytokines
Interleukin 17
endocrine system
Macromolecular Substances
T cell
Molecular Sequence Data
Immunology
Biology
Transfection
Dinoprostone
Herpesvirus 2
Saimiriine
Proinflammatory cytokine
Interferon-gamma
Open Reading Frames
Viral Proteins
Immune system
Antigen
medicine
Animals
Humans
Amino Acid Sequence
Interleukin 8
Inflammation
Base Sequence
Sequence Homology
Amino Acid
Interleukin-6
Tumor Necrosis Factor-alpha
Interleukins
Interleukin-8
Fibroblasts
Hematopoietic Stem Cells
Hematopoiesis
Endothelium
Vascular
Stromal Cells
Zdroj: The Journal of Experimental Medicine
ISSN: 1540-9538
0022-1007
DOI: 10.1084/jem.183.6.2593
Popis: Analysis of the cDNA encoding murine interleukin (IL) 17 (cytotoxic T lymphocyte associated antigen 8) predicted a secreted protein sharing 57% amino acid identity with the protein predicted from ORF13, an open reading frame of Herpesvirus saimiri. Here we report on the cloning of human IL-17 (hIL-17), the human counterpart of murine IL-17. hIL-17 is a glycoprotein of 155 amino acids secreted as an homodimer by activated memory CD4+ T cells. Although devoid of direct effects on cells of hematopoietic origin, hIL-17 and the product of its viral counterpart, ORF13, stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and granulocyte-colony-stimulating factor, as well as prostaglandin E2. Furthermore, when cultured in the presence of hIL-17, fibroblasts could sustain the proliferation of CD34+ hematopoietic progenitors and their preferential maturation into neutrophils. These observations suggest that hIL-17 may constitute (a) an early initiator of the T cell-dependent inflammmatory reaction; and (b) an element of the cytokine network that bridges the immune system to hematopoiesis.
Databáze: OpenAIRE
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