Nasal mucosa healing after endoscopic sinus surgery in chronic rhinosinusitis of elderly patients: role of topic alpha-tocopherol acetate

Autor: Domenico Testa, Germano Guerra, Pasquale Piombino, Andrea Bianco, Michele Nunziata, Giuseppina Marcuccio, Gaetano Motta, Domenico Tafuri, Francesco Zappoli Thyrion, Giorgio Panin
Přispěvatelé: Testa, Domenico, Marcuccio, Giuseppina, Panin, Giorgio, Bianco, Andrea, Tafuri, Domenico, Thyrion, Francesco Zappoli, Nunziata, Michele, Piombino, Pasquale, Guerra, Germano, Motta, Gaetano, Testa, D., Marcuccio, G., Panin, G., Bianco, A., Tafuri, D., Thyrion, F. Z., Nunziata, M., Piombino, P., Guerra, G., Motta, G.
Rok vydání: 2016
Předmět:
Male
Aging
Chronic rhinosinusitis
Administration
Topical
Rhinoscopy Sum Score (RSS)
alpha-Tocopherol
Paranasal Sinuse
Mucous membrane of nose
Antioxidants
chemistry.chemical_compound
Postoperative Complications
0302 clinical medicine
Quality of life
Paranasal Sinuses
Medicine
030223 otorhinolaryngology
Rhiniti
Rhinitis
education.field_of_study
Alpha-tocopherol acetate
Treatment Outcome
Topical
030220 oncology & carcinogenesis
Administration
Female
Antioxidant
Human
Natural Orifice Endoscopic Surgery
medicine.medical_specialty
Mucociliary clearance
Population
03 medical and health sciences
Atrophy
Humans
Sinusitis
education
Chronic rhinosinusitis (CRS)
Functional endoscopic sinonasal surgery (FESS)
Nasal mucosa
Aged
Chronic Disease
Nasal Mucosa
Quality of Life
Geriatrics and Gerontology
business.industry
medicine.disease
Surgery
Endoscopic sinus surgery
chemistry
Postoperative Complication
business
Zdroj: Aging Clinical and Experimental Research. 29:191-195
ISSN: 1720-8319
DOI: 10.1007/s40520-016-0647-x
Popis: Background: Chronic rhinosinusitis (CRS) in European country ranges in elderly patients from 4.5 to 12% of population and has a significant effect on quality of life. In these patients, rhinosinusitis is linked to immune functions changes with age and to mucosal paraphysiological alterations such as crusting formations with atrophic epithelium, variations of nasal airflow and modifications of the mucociliary clearance. Failure of medical treatments leads to surgery in patients with persistent symptoms and radiographic signs of CRS. The choice of appropriate post-surgical topic treatments is important for healing time and for preventing mucosal complications such as synechiae, crusting formation and atrophy with secondary bacterial and fungal infections. Aims: Defining the effects of topic alpha-tocopherol acetate administration on nasal mucosa healing after endoscopic sinus surgery in CRS of elderly patients. Methods: In this study were included 32 patients, mean age 68.6, who underwent FESS because affected by CRS not responsive to medical treatments. After surgical treatment, we distinguish two groups basing on local nasal therapy. Results: We investigated, in the postoperative time, the role of alpha-tocopherol acetate compared to gomenol oil. Follow-up was performed at 7–15 days and 1–3 months after surgery. We evaluated mucosal restoration using Rhinoscopy Sum Score and quality of life using Nasal Six Items Symptom Questionnaire. We observed a faster healing time and less recurrence of complications in patients who underwent topic treatment with alpha-tocopherol acetate. Discussion: In our research, we observed that alpha-tocopherol acetate has no contraindications and side effects. Conclusions: Our study showed the effectiveness of alpha-tocopherol acetate topic treatment in elderly patients affected by CRS after FESS, in improving and speeding up the process of restoring the sinonasal mucosa, compared to another topic medication.
Databáze: OpenAIRE
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