Retinal Vein Occlusion in a Multi-Ethnic Asian Population: The Singapore Epidemiology of Eye Disease Study

Autor:	Jie Jin Wang, Paul Mitchell, Victor Koh, Carol Y. Cheung, Xiang Li, Ching-Yu Cheng, Tien Yin Wong, Dechao Tian
Rok vydání:	2016
Předmět:	Adult Male medicine.medical_specialty Epidemiology Eye disease Population Visual Acuity Prevalence 03 medical and health sciences 0302 clinical medicine Asian People Central retinal vein occlusion Risk Factors Internal medicine Retinal Vein Occlusion Ethnicity medicine Humans 030212 general & internal medicine education Aged Malay Aged 80 and over Singapore education.field_of_study business.industry Middle Aged medicine.disease Confidence interval language.human_language Ophthalmology 030221 ophthalmology & optometry language Branch retinal vein occlusion Optometry Female business
Zdroj:	Ophthalmic Epidemiology. 23:6-13
ISSN:	1744-5086 0928-6586
Popis:	To describe the prevalence of retinal vein occlusion (RVO) and its risk factors in a multi-ethnic Asian population.This population-based study of 10,033 participants (75.7% response rate) included Chinese, Indian and Malay persons aged 40 years and older. A comprehensive ophthalmic examination, standardized interviews and laboratory blood tests were performed. Digital fundus photographs were assessed for presence of RVO following the definitions used in the Blue Mountains Eye Study. Regression analysis models were constructed to study the relationship between ocular and systemic factors and RVO. Age-specific prevalence rates of RVO were applied to project the number of people affected in Asia from 2013 to 2040.The overall crude prevalence of RVO was 0.72% (n = 71; 95% confidence interval, CI, 0.54-0.87%). The crude prevalence of RVO was similar in Chinese, Indian and Malay participants (p = 0.865). In multivariable regression models, significant risk factors of RVO included increased age (odds ratio, OR, 1.03, 95% CI 1.01-1.06), hypertension (OR 3.65, 95% CI 1.61-8.31), increased serum creatinine (OR 1.04, 95% CI 1.01-1.06, per 10 mmol/L increase), history of heart attack (OR 2.25, 95% CI 1.11-4.54) and increased total cholesterol (OR 1.31, 95% CI 1.07-1.59, per 1 mmol/L increase). None of the ocular parameters were associated with RVO. RVO is estimated to affect up to 16 and 21 million people in Asia by 2020 and 2040, respectively.RVO was detected in 0.72% of a multi-ethnic Asian population aged 40-80 years in Singapore. The significant systemic risk factors of RVO are consistent with studies in white populations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a0d85deb6c90b412665125d6038167 https://doi.org/10.3109/09286586.2015.1082604 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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