Effects of cholecalciferol supplementation on serum and urinary vitamin D metabolites and binding protein in HIV-infected youth

Autor:	Mary Ann O'Riordan, Danielle Labbato, Julie E. Daniels, Vin Tangpricha, Natalia Silvestrov, Monika Uribe-Leitz, Julia C. Rosebush, Ravinder J. Singh, Joshua H. Ruff, Grace A. McComsey, Myrtle Thierry-Palmer, Allison Ross Eckard
Rok vydání:	2017
Předmět:	Adult Cyclopropanes Male 0301 basic medicine Vitamin medicine.medical_specialty Efavirenz Adolescent Vitamin D-binding protein Endocrinology Diabetes and Metabolism Clinical Biochemistry HIV Infections Biochemistry Article vitamin D deficiency law.invention Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Double-Blind Method Randomized controlled trial law Internal medicine medicine Vitamin D and neurology Humans 030212 general & internal medicine Vitamin D Molecular Biology Cholecalciferol business.industry Vitamin D-Binding Protein Parallel study Cell Biology Vitamin D Deficiency medicine.disease 030112 virology Benzoxazines chemistry Alkynes Dietary Supplements Molecular Medicine Female business Protein Binding
Zdroj:	The Journal of Steroid Biochemistry and Molecular Biology. 168:38-48
ISSN:	0960-0760
Popis:	Vitamin D insufficiency is widespread in HIV-infected patients. HIV and/or antiretroviral therapy (ART), particularly efavirenz (EFV), may interfere with vitamin D metabolism. However, few data from randomized, controlled trials exist. Here, we investigate changes in vitamin D metabolites and binding protein (VDBP) after 6 months of supplementation in a randomized, active-control, double-blind trial investigating 2 different monthly cholecalciferol (vitamin D3) doses [60,000 (medium) or 120,000 (high) IU/month] vs. a control arm of 18,000 IU/month in 8–25 year old HIV-infected youth on ART with HIV-1 RNA
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::909ebbf571e6071a1d19b4b28ac997a1 https://doi.org/10.1016/j.jsbmb.2017.01.018 Zobrazit plný text záznamu Full Text from ScienceDirect