Efficacy and tolerance of diclofenac sodium 0.1%, flurbiprofen 0.03%, and indomethacin 1.0% in controlling postoperative inflammation
| Autor: | Michael Diestelhorst, Ulrich Mester, Palaniswamy Sunder Raj, Bernhard Schmidl, Walter Konen |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Diclofenac Administration Topical medicine.medical_treatment Indomethacin Flurbiprofen Intraocular lens Postoperative Complications Endophthalmitis Double-Blind Method medicine Humans Prospective Studies Prospective cohort study Lenses Intraocular Phacoemulsification business.industry Anti-Inflammatory Agents Non-Steroidal Diclofenac Sodium medicine.disease Sensory Systems Ophthalmology Treatment Outcome Anesthesia Female Surgery Ophthalmic Solutions Complication business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Cataract and Refractive Surgery. 22:788-793 |
| ISSN: | 0886-3350 |
| DOI: | 10.1016/s0886-3350(96)80163-5 |
| Popis: | Purpose: To compare the anti-inflammatory effect of diclofenac sodium 0.1 % ophthalmic solution, flurbiprofen 0.03% ophthalmic solution, and indomethacin 1.0%. Setting: Department of Ophthalmology, University of Koln, and Bundesknappschaftskrankenhaus, Sulzbach, Germany. Methods: One hundred seventeen patients enrolled in this prospective, randomized, double-masked, and parallel-group study had phacoemulsification and intraocular lens implantation and received one of the three solutions. Preoperatively at day 1 and postoperatively at day 4 or 5 and day 12, 13, or 14, they were examined by slitlamp, applanation tonometry, and laser flare meter. Results: Anterior chamber flare reduction from baseline was significantly greater in the diclofenac group than in the flurbiprofen group ( P = .022). Patients in the diclofenac group had significantly less burning and stinging than those in the flurbiprofen and indomethacin groups at postoperative days 4–5 and 12–14 ( P = .001). Conclusion: Diclofenac sodium appeared to be more potent than flurbiprofen in controlling intraocular inflammation after cataract surgery and appeared to be locally tolerated better than flurbiprofen and indomethacin. |
| Databáze: | OpenAIRE |
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