The Role of Epigenetics in the Developmental Origins of Health and Disease
| Autor: | Karin B. Michels, Robert A. Waterland |
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| Rok vydání: | 2022 |
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| Zdroj: | Epigenetic Epidemiology ISBN: 9783030944742 Epigenetic Epidemiology ISBN: 9789400724945 |
| Popis: | The Developmental Origins of Health and Disease (DOHaD) hypothesis suggests that the prenatal and early postnatal environments shape the future probability of physical and mental wellbeing and risk of disease. A wealth of epidemiologic data supports the associations between maternal malnutrition, intrauterine growth retardation, and birthweight, and the risk of chronic disease including cardiovascular disease, hypertension, type 2 diabetes mellitus, obesity, neuropsychiatric disorders, and cancer. While the mechanisms underlying these observations remain unresolved, the DOHaD model assumes a developmental plasticity that allows adaptive regulation of the embryonic, fetal, and/or early postnatal metabolism in response to nutritional and environmental perturbations. Establishment of the epigenome coincides with vulnerable phases in development and provides one potential mechanism for long-lasting responses to transient environmental stimuli. Future studies in epigenetic epidemiology will seek to understand the role of various epigenetic mechanisms in DOHaD. |
| Databáze: | OpenAIRE |
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