Effect of psychotropic drugs on cortical excitability of patients with major depressive disorders: A transcranial magnetic stimulation study
| Autor: | Amr M. Galal, Mostafa M. Noaman, Ahmed A. Abdelrahman, Eman M. Khedr, Mohamed Fawzy, Yasser M. Elserogy |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Olanzapine medicine.drug_class medicine.medical_treatment Serotonin reuptake inhibitor Atypical antipsychotic Pharmacology Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Biological Psychiatry Psychiatric Status Rating Scales Depressive Disorder Major Sertraline business.industry Motor Cortex Evoked Potentials Motor medicine.disease Transcranial Magnetic Stimulation 030227 psychiatry Transcranial magnetic stimulation Psychiatry and Mental health medicine.anatomical_structure Cortical Excitability Major depressive disorder Quetiapine Female business 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug Motor cortex |
| Zdroj: | Psychiatry Research. 291:113287 |
| ISSN: | 0165-1781 |
| DOI: | 10.1016/j.psychres.2020.113287 |
| Popis: | Transcranial magnetic stimulation (TMS) can be used to evaluate the effects of pharmacological interventions. The aim of this study was to assess the impact of the selective serotonin reuptake inhibitor, sertraline, and the atypical antipsychotic drugs quetiapine and olanzapine, on cortical excitability in unmedicated patients with major depressive disorder (MDD). The study included 45 medication-free MDD patients diagnosed according to DSM V. They were divided randomly into three groups who received a single oral dose of one of the three drugs sertraline (50 mg), quetiapine (100 mg) and olanzapine (10 mg). Psychological evaluation was conducted using the Mini-Mental State Examination (MMSE) and Beck Depression Inventory Scale (BDI). Resting and active motor thresholds (rMT and aMT) together with contralateral and ipsilateral cortical silent periods (cSP, and iSP) were measured for each participant before and at the time of maximum concentration of drug intake. There was significant increase in excitability of motor cortex after sertraline without changes in GABAB neurotransmission. Quetiapine and olanzapine potentiated inhibitory GABAB neurotransmission (prolongation of cSP); olanzapine additionally prolonged the iSP. Thus TMS can differentiate between the impact of different psychotropic drugs on excitatory and inhibitory transmission in motor cortex. |
| Databáze: | OpenAIRE |
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