Women with a Reduced Ovarian Complement May Have an Increased Risk for a Child with Down Syndrome
| Autor: | Lisa Taft, Sallie B. Freeman, Quanhe Yang, Stephanie L. Sherman, Katherine Allran |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Adult
medicine.medical_specialty Down syndrome Oophorectomy Trisomy 21 Adolescent Ovariectomy Pregnancy High-Risk medicine.medical_treatment Physiology Ovary Biology Nondisjunction 03 medical and health sciences 0302 clinical medicine Nondisjunction Genetic Risk Factors Prenatal Diagnosis Surveys and Questionnaires Internal medicine Odds Ratio Genetics medicine Humans Genetics(clinical) Advanced maternal age Risk factor Menstrual Cycle Genetics (clinical) 030304 developmental biology 0303 health sciences 030219 obstetrics & reproductive medicine Case-control study Odds ratio medicine.disease Meiosis Endocrinology medicine.anatomical_structure Case-Control Studies Female Follicle Stimulating Hormone Trisomy Maternal Age Research Article |
| Zdroj: | The American Journal of Human Genetics. (5):1680-1683 |
| ISSN: | 0002-9297 |
| DOI: | 10.1086/302907 |
| Popis: | Advanced maternal age is the only well-established risk factor for trisomy 21 Down syndrome (DS), but the basis of the maternal-age effect is not known. In a population-based, case-control study of DS, women who reported surgical removal of all or part of an ovary or congenital absence of one ovary were significantly more likely to have delivered a child with DS than were women who did not report a reduced ovarian complement (odds ratio 9.61; 95% confidence interval 1.18-446.3). Because others have observed that women who have had an ovary removed exhibit elevated levels of FSH and similar hallmarks of advanced maternal age, our finding suggests that the physiological status of the ovary is key to the maternal-age effect. In addition, it suggests that women with a reduced ovarian complement should be offered prenatal diagnosis. |
| Databáze: | OpenAIRE |
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