Asymmetric Biocatalytic Amination of Ketones at the Expense of NH3 and Molecular Hydrogen

Autor:	Oliver Lenz, Lars Lauterbach, Katharina Hiebler, Francesco G. Mutti, Wolfgang Kroutil, Anja K. Holzer, Robert C. Simon
Rok vydání:	2015
Předmět:	Hydrogenase Molecular Structure Chemistry Alanine dehydrogenase Organic Chemistry Hydrogen molecule Ketones Biochemistry Biocatalysis Ammonia Organic chemistry Molecule Stereoselectivity NAD+ kinase Physical and Theoretical Chemistry Amines Amination Hydrogen
Zdroj:	Organic letters. 17(10)
ISSN:	1523-7052
Popis:	A biocatalytic system is presented for the stereoselective amination of ketones at the expense of NH3 and molecular hydrogen. By using a NAD(+)-reducing hydrogenase, an alanine dehydrogenase, and a suitable ω-transaminase, the R- as well as the S-enantiomer of various amines could be prepared with up to >99% ee and 98% conversion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::908bcf1cd1626e0ff4b4ab1ed688fdee https://pubmed.ncbi.nlm.nih.gov/25946312 Zobrazit plný text záznamu