Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

Autor: Marie Vognstoft Hjortbak, Steen Larsen, Pernille Tilma Tonnesen, Hans Erik Bøtker, Nicolaj B. Støttrup, Nichlas Riise Jespersen, Hans-Henrik Kimose, Jacob Johnsen, Thomas Ravn Lassen
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Myocardial Infarction
030204 cardiovascular system & hematology
0302 clinical medicine
Cardioprotection
Multidisciplinary
biology
Molecular medicine
Succinate dehydrogenase
Heart
Middle Aged
Mitochondria
Succinate Dehydrogenase
Treatment Outcome
Ischemic Preconditioning
Myocardial
Medicine
Female
medicine.medical_specialty
Cardiotonic Agents
Science
Ischemia
Myocardial Reperfusion Injury
Article
03 medical and health sciences
Therapeutic index
Diabetes mellitus
Internal medicine
Respiration
medicine
Animals
Humans
Aged
business.industry
Myocardium
Isolated Heart Preparation
medicine.disease
Myocardial Contraction
Malonates
Cardiovascular biology
Rats
Rats
Zucker
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
biology.protein
Ischemic preconditioning
business
Zdroj: Scientific Reports
Jespersen, N R, Hjortbak, M V, Lassen, T R, Støttrup, N B, Johnsen, J, Tonnesen, P T, Larsen, S, Kimose, H-H & Bøtker, H E 2020, ' Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus ', Scientific Reports, vol. 10, no. 1, 10344 . https://doi.org/10.1038/s41598-020-67247-4
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Jespersen, N R, Hjortbak, M V, Lassen, T R, Støttrup, N B, Johnsen, J, Tonnesen, P T, Larsen, S, Kimose, H H & Bøtker, H E 2020, ' Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus ', Scientific Reports, vol. 10, no. 1, 10344 . https://doi.org/10.1038/s41598-020-67247-4
ISSN: 2045-2322
DOI: 10.1038/s41598-020-67247-4
Popis: Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH) inhibition by dimethyl malonate (DiMAL). Whether SDH inhibition yields protection in diabetic individuals and translates into human cardiac tissue remain unknown. In isolated perfused hearts from 24 weeks old male Zucker diabetic fatty (ZDF) and age matched non-diabetic control rats and atrial trabeculae from patients with and without diabetes, we compared infarct size, contractile force recovery and mitochondrial function. The cardioprotective effect of a 10 minutes DiMAL administration prior to global ischemia and ischemic preconditioning (IPC) was evaluated. In non-diabetic hearts exposed to IR, DiMAL 0.1 mM reduced infarct size compared to IR (55 ± 7% vs. 69 ± 6%, p
Databáze: OpenAIRE
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