High intra-individual variability of cyclosporine pharmacokinetics in lung transplant recipients without cystic fibrosis

Autor:	Víctor Monforte, Leonor Pou, Alejandra Méndez, Antonio Roman, Cristina Berastegui, Manuel López-Meseguer, Carlos Bravo
Rok vydání:	2014
Předmět:	Lung Diseases Male medicine.medical_specialty Cystic Fibrosis Coefficient of variation medicine.medical_treatment Single Center Cystic fibrosis Gastroenterology Cohort Studies Individuation Pharmacokinetics Internal medicine medicine Humans Lung transplantation Transplantation Lung business.industry Immunosuppression Middle Aged Prognosis medicine.disease Intra individual Transplant Recipients Surgery medicine.anatomical_structure Cyclosporine Female business Immunosuppressive Agents Follow-Up Studies Lung Transplantation
Zdroj:	Clinical Transplantation. 28:743-748
ISSN:	0902-0063
DOI:	10.1111/ctr.12371
Popis:	Background There has been little study on the variability of CsA pharmacokinetics in stable lung transplant (LT) recipients without cystic fibrosis. This study was conducted to determine the prevalence of high intra-individual variability of CsA in LT recipients and its implications in CsA monitoring. Methods Twenty-nine pharmacokinetic curves were performed in 10 consecutive stable patients from a single center. The intra-individual coefficient of variation (CV) of the AUC0–12 h was calculated in each case. Patients were grouped according to whether their CV was high (≥20%) or low (
Databáze:	OpenAIRE
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