| Autor: |
Linbao, Zhang, Yong, Liu, Haigang, Chen, Wengui, Cai |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 257:109333 |
| ISSN: |
1532-0456 |
| DOI: |
10.1016/j.cbpc.2022.109333 |
| Popis: |
Triazophos (TP) is a widespread pollutant in aquatic environments. A sex-specific metabolic response in green-lipped mussel Perna viridis to TP exposure was observed in our previous study, and this led us to investigate the mechanisms associated with its toxicity. P. viridis were subjected to chronic exposure (15 days) to TP at 35 μg/L to compare the sex-biased transcriptomic profiles in the gonads of male and female mussels. We identified 632 differentially expressed genes (DEGs) (348 up-regulated and 284 down-regulated) in TP-exposed males, and only 61 DEGs (9 up-regulated and 52 down-regulated) in TP-exposed females. Many DEGs were found to be involved in the nervous, reproductive endocrine, oxidative stress, and immune systems of P. viridis. Additionally, enzymatic activity analysis indicated TP induced neurotoxic effects and oxidative damage to the mussels. Our results demonstrate that the stress response and molecular mechanisms of TP toxicology are different between female and male mussels. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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