Suggestions to Reduce Clinical Fibromyalgia Pain and Experimentally Induced Pain Produce Parallel Effects on Perceived Pain but Divergent Functional MRI–Based Brain Activity
| Autor: | Matthew G. Whalley, Stuart W. G. Derbyshire, David A. Oakley, T H Stanley Seah |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
Fibromyalgia Brain activity and meditation HGSHS = Harvard Group Scale of Hypnotic Susceptibility ICA = independent components analysis Hypnotic 0302 clinical medicine Thalamus BA = Brodman area ROI = region of interest Suggestion Applied Psychology medicine.diagnostic_test 05 social sciences Pain Perception Cognition Middle Aged pACC = perigenual anterior cingulate Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure experimental pain Anesthesia ComputingMethodologies_DOCUMENTANDTEXTPROCESSING hypnosis Female chronic pain Adult medicine.medical_specialty medicine.drug_class brain Pain HADS = Hospital Anxiety And Depression Scale Gyrus Cinguli PAG = periaqueductal gray 050105 experimental psychology alternative therapy 03 medical and health sciences BOLD = blood oxygen level dependent Physical medicine and rehabilitation medicine Humans Pain Management S2 = secondary somatosensory cortex 0501 psychology and cognitive sciences FM = fibromyalgia Anterior cingulate cortex business.industry Magnetic resonance imaging Original Articles S1 = primary somatosensory cortex medicine.disease functional magnetic resonance imaging FSL = FMRIB software library MRI = magnetic resonance imaging aMCC = anterior mid-cingulate cortex Functional magnetic resonance imaging business 030217 neurology & neurosurgery |
| Zdroj: | Psychosomatic Medicine |
| ISSN: | 1534-7796 0033-3174 |
| Popis: | Supplemental digital content is available in the text. Objective Hypnotic suggestion is an empirically validated form of pain control; however, the underlying mechanism remains unclear. Methods Thirteen fibromyalgia patients received suggestions to alter their clinical pain, and 15 healthy controls received suggestions to alter experimental heat pain. Suggestions were delivered before and after hypnotic induction with blood oxygen level–dependent (BOLD) activity measured concurrently. Results Across groups, suggestion produced substantial changes in pain report (main effect of suggestion, F2, 312 = 585.8; p < .0001), with marginally larger changes after induction (main effect of induction, F1, 312 = 3.6; p = .060). In patients, BOLD response increased with pain report in regions previously associated with pain, including thalamus and anterior cingulate cortex. In controls, BOLD response decreased with pain report. All changes were greater after induction. Region-of-interest analysis revealed largely linear patient responses with increasing pain report. Control responses, however, were higher after suggestion to increase or decrease pain from baseline. Conclusions Based on behavioral report alone, the mechanism of suggestion could be interpreted as largely similar regardless of the induction or type of pain experience. The functional magnetic resonance imaging data, however, demonstrated larger changes in brain activity after induction and a radically different pattern of brain activity for clinical pain compared with experimental pain. These findings imply that induction has an important effect on underlying neural activity mediating the effects of suggestion, and the mechanism of suggestion in patients altering clinical pain differs from that in controls altering experimental pain. Patient responses imply that suggestions altered pain experience via corresponding changes in pain-related brain regions, whereas control responses imply suggestion engaged cognitive control. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|